Male fertility has deteriorated over the last decades, and environmental risk factors are
among the possible causes of this phenomenon. Pollutants such as heavy metals might …

BACKGROUND Spermatozoa acquire their motility and fertilizing abilities during their
maturation through the epididymis. This process is controlled by epididymal epithelial cells …

STUDY QUESTION Are epididymosomes implicated in protein transfer from the epididymis
to spermatozoa? SUMMARY ANSWER We characterized the contribution of epididymal …

Spermatozoa acquire their fertilizing ability and forward motility during epididymal transit,
suggesting the importance of the epididymis. Although the cell atlas of the epididymis was …

Regulatory T cells (Tregs) modulate tissue homeostatic processes and immune responses.
Understanding tissue-Treg biology will contribute to developing precision-targeting …

Paternal exposure to environmental stressors elicits distinct changes to the sperm sncRNA
profile, modifications that have significant post-fertilization consequences. Despite this …

The epididymis is a tubular structure connecting the vas deferens to the testis. This organ
consists of three main regions—caput, corpus, and cauda—that face opposing …

Introduction One of the most intriguing aspects of male reproductive physiology is the ability
of the epididymis to prevent the mounting of immune responses against the onslaught of …

Mononuclear phagocytes (MPs) play an active role in the immunological homeostasis of the
urogenital tract. In the epididymis, a finely tuned balance between tolerance to antigenic …

Ascending bacterial urinary tract infections can cause epididymo-orchitis. In the cauda
epididymidis, this frequently leads to persistent tissue damage. Less coherent data is …