The view of cancer as a tumor cell-centric disease is now replaced by our understanding of
the interconnection and dependency of tumor stroma. Cancer-associated fibroblasts (CAFs) …

The biology of solid tumors is strongly determined by the interactions of cancer cells with
their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal …

Pancreatic ductal adenocarcinoma carries a dismal prognosis, and outcomes have
improved little with modern therapeutics. Checkpoint-based immunotherapy has failed to …

The immunotherapeutic treatment of various cancers with an increasing number of immune
checkpoint inhibitors (ICIs) has profoundly improved the clinical management of advanced …

Simple Summary In pancreatic cancer, immunotherapy and targeted therapies have not
brought about the therapeutic revolution that has been observed in other malignancies …

Cancer immunotherapy has opened a new landscape in cancer treatment, however, the
poor specificity and resistance of most targeted therapeutics have limited their therapeutic …

Macrophage-targeting therapies have become attractive strategies for immunotherapy.
Deficiency of MARCO significantly inhibits tumor progression and metastasis in murine …

Pancreatic cancer (PC) is the most lethal malignancy worldwide due to its delayed diagnosis
and limited treatment options. Despite great progress in clinical trials of immunotherapies for …

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies and is
characterized by a unique tumor microenvironment (TME) consisting of an abundant stromal …

Preclinical data demonstrate that the gut microbiota can promote pancreatic ductal
adenocarcinoma (PDAC), but mechanisms remain unclear. We hypothesized that intestinal …