The binding of drugs to plasma proteins, such as albumin and a1-acid glycoprotein (AGP) is
a major determinant in the disposition of drugs. A topology analysis of drug binding sites on …

Glycosylation is one of the most important post-translational modifications of proteins, and
has been widely acknowledged as one of the most important ways to modulate both protein …

Proteins display interesting chiral discrimination properties owing to multiple possibilities of
intermolecular interactions with chiral compounds. This review deals with proteins which …

α1-Acid glycoprotein (AGP) is an important drug-binding protein in human plasma and, as
an acute-phase protein, it has a strong influence on pharmacokinetics and …

Brigatinib, a multi-target kinase inhibitor, is primarily used to treat anaplastic lymphoma
kinase (ALK)-positive patients with advanced non-small cell lung cancer (NSCLC) who have …

Secondary and tertiary structures of human blood α1-acid glycoprotein, a member of the
lipocalin family, have been studied for the first time by infrared and Raman spectroscopies …

The properties of singlet and triplet excited states are strongly medium-dependent. Hence,
these species constitute valuable tools as reporters to probe compartmentalised …

Membrane proteins, although constituting about one-third of all proteins encoded by the
genomes of living organisms, are still strongly underrepresented in the database of 3D …

A powerful Janus kinase (JAK) inhibitor, ocalcitinib has been authorized for controlling
pruritus and atopic dermatitis from canine allergic dermatitis and many kinds of cytokines. To …

Alpha-1 acid glycoprotein (AGP, orosomucoid), a major acute phase protein in plasma,
displays potent cytoprotective and anti-inflammatory activities whose molecular mechanisms …