The glutamate dehydrogenase pathway and its roles in cell and tissue biology in health and disease
A Plaitakis, E Kalef-Ezra, D Kotzamani, I Zaganas… - Biology, 2017 - mdpi.com
Glutamate dehydrogenase (GDH) is a hexameric enzyme that catalyzes the reversible
conversion of glutamate to α-ketoglutarate and ammonia while reducing NAD (P)+ to NAD …
conversion of glutamate to α-ketoglutarate and ammonia while reducing NAD (P)+ to NAD …
Evolutionary Changes in Primate Glutamate Dehydrogenases 1 and 2 Influence the Protein Regulation by Ligands, Targeting and Posttranslational Modifications
YA Aleshina, VA Aleshin - International Journal of Molecular Sciences, 2024 - mdpi.com
There are two paralogs of glutamate dehydrogenase (GDH) in humans encoded by the
GLUD1 and GLUD2 genes as a result of a recent retroposition during the evolution of …
GLUD1 and GLUD2 genes as a result of a recent retroposition during the evolution of …
Human GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cells
Mammalian glutamate dehydrogenase (GDH) is an allosterically regulated enzyme that is
expressed widely. Its activity is potently inhibited by GTP and thought to be controlled by the …
expressed widely. Its activity is potently inhibited by GTP and thought to be controlled by the …
The human GLUD2 glutamate dehydrogenase and its regulation in health and disease
A Plaitakis, H Latsoudis, C Spanaki - Neurochemistry international, 2011 - Elsevier
Whereas glutamate dehydrogenase in most mammals (hGDH1 in the human) is encoded by
a single functional GLUD1 gene expressed widely, humans and other primates have …
a single functional GLUD1 gene expressed widely, humans and other primates have …
Expression of human GLUD2 glutamate dehydrogenase in human tissues: functional implications
Glutamate dehydrogenase (GDH), a mitochondrial enzyme with a key metabolic role, exists
in the human in hGDH1 and hGDH2 isoforms encoded by the GLUD1 and GLUD2 genes …
in the human in hGDH1 and hGDH2 isoforms encoded by the GLUD1 and GLUD2 genes …
Deregulation of glutamate dehydrogenase in human neurologic disorders
Mammalian glutamate dehydrogenase is an allosterically regulated enzyme that is central to
glutamate metabolism. It contributes to important cellular processes, including Krebs cycle …
glutamate metabolism. It contributes to important cellular processes, including Krebs cycle …
Evolution of Glutamate Metabolism via GLUD2 Enhances Lactate-Dependent Synaptic Plasticity and Complex Cognition
A Plaitakis, K Sidiropoulou, D Kotzamani, I Litso… - International Journal of …, 2024 - mdpi.com
Human evolution is characterized by rapid brain enlargement and the emergence of unique
cognitive abilities. Besides its distinctive cytoarchitectural organization and extensive inter …
cognitive abilities. Besides its distinctive cytoarchitectural organization and extensive inter …
Estrogen modification of human glutamate dehydrogenases is linked to enzyme activation state
N Borompokas, MM Papachatzaki… - Journal of Biological …, 2010 - ASBMB
Mammalian glutamate dehydrogenase (GDH) is a housekeeping enzyme central to the
metabolism of glutamate. Its activity is potently inhibited by GTP (IC 50= 0.1–0.3 μm) and …
metabolism of glutamate. Its activity is potently inhibited by GTP (IC 50= 0.1–0.3 μm) and …
The odyssey of a young gene: structure–function studies in human glutamate dehydrogenases reveal evolutionary-acquired complex allosteric regulation …
IV Zaganas, K Kanavouras, N Borompokas… - Neurochemical …, 2014 - Springer
Mammalian glutamate dehydrogenase (GDH) catalyzes the reversible inter-conversion of
glutamate to α-ketoglutarate and ammonia, interconnecting carbon skeleton and nitrogen …
glutamate to α-ketoglutarate and ammonia, interconnecting carbon skeleton and nitrogen …
Dissecting the antenna in human glutamate dehydrogenase: understanding its role in subunit communication and allosteric regulation
ZA Hoffpauir, E Sherman, TJ Smith - Biochemistry, 2019 - ACS Publications
Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible
oxidative deamination of l-glutamate. While GDH is found in all living organisms, only that …
oxidative deamination of l-glutamate. While GDH is found in all living organisms, only that …