Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma
but also a network of membrane invaginations called transverse (t-) tubules. These …

Ryanodine receptors (RyRs) exhibit dynamic arrangements in cardiomyocytes, and we
previously showed that 'dispersion'of RyR clusters disrupts Ca 2+ homeostasis during heart …

Each heartbeat begins with the generation of an action potential in pacemaking cells in the
sinoatrial node. This signal triggers contraction of cardiac muscle through a process termed …

The architectural specializations and targeted delivery pathways of cardiomyocytes ensure
that L-type Ca2+ channels (CaV1. 2) are concentrated on the t-tubule sarcolemma within …

Cardiac multiscale bioimaging is an emerging field that aims to provide a comprehensive
understanding of the heart and its functions at various levels, from the molecular to the entire …

This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …

Ca2+ sparks constitute the fundamental units of Ca2+ release in cardiomyocytes. Here we
investigate how ryanodine receptors (RyRs) collectively generate these events by …

Earlier work has shown that ventricular ryanodine receptors (RyR2) within a cluster
rearrange on phosphorylation as well as with a number of other stimuli. Using dSTORM, we …

Clusters of ryanodine receptor calcium channels (RyRs) form the primary molecular
machinery of intracellular calcium signalling in cardiomyocytes. While a range of optical …