A conserved mechanism couples cytosolic domain movements to pore gating in the TRPM2 channel
B Tóth, Y Jiang, A Szollosi, Z Zhang… - Proceedings of the …, 2024 - pnas.org
Transient Receptor Potential Melastatin 2 (TRPM2) cation channels contribute to
immunocyte activation, insulin secretion, and central thermoregulation. TRPM2 opens upon …
immunocyte activation, insulin secretion, and central thermoregulation. TRPM2 opens upon …
[HTML][HTML] Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium
C Ma, Y Luo, C Zhang, C Cheng, N Hua, X Liu, J Wu… - Science Bulletin, 2024 - Elsevier
Ion channel activation upon ligand gating triggers a myriad of biological events and,
therefore, evolution of ligand gating mechanism is of fundamental importance. TRPM2, a …
therefore, evolution of ligand gating mechanism is of fundamental importance. TRPM2, a …
The essential inter-domain interaction between NUDT9H and channel domain of human TRPM2 is also accomplished in trans
W Ehrlich, FJP Kühn - bioRxiv, 2023 - biorxiv.org
Channel function of human transient receptor potential melastatin type 2 (hsTRPM2)
essentially depends on its C-terminal domain NUDT9H, which is homologous to the human …
essentially depends on its C-terminal domain NUDT9H, which is homologous to the human …