Modeling Alzheimer's Disease in Caenorhabditis elegans

J Alvarez, P Alvarez-Illera, J Santo-Domingo… - Biomedicines, 2022 - mdpi.com
Alzheimer's disease (AD) is the most frequent cause of dementia. After decades of research,
we know the importance of the accumulation of protein aggregates such as β-amyloid …

Unlocking novel therapies: Cyclic peptide design for amyloidogenic targets through synergies of experiments, simulations, and machine learning

D de Raffele, IM Ilie - Chemical Communications, 2024 - pubs.rsc.org
Existing therapies for neurodegenerative diseases like Parkinson's and Alzheimer's address
only their symptoms and do not prevent disease onset. Common therapeutic agents, such as …

Exendin-4 alleviates β-Amyloid peptide toxicity via DAF-16 in a Caenorhabditis elegans model of Alzheimer's disease

X Song, Y Sun, Z Wang, Y Su, Y Wang… - Frontiers in aging …, 2022 - frontiersin.org
Epidemiological analyses indicate that type 2 diabetes mellitus (T2DM) is a risk factor for
Alzheimer's disease (AD). They share common pathophysiological mechanisms. Thus, it has …

Carnosic acid ameliorated Aβ-mediated (amyloid-β peptide) toxicity, cholinergic dysfunction and mitochondrial defect in Caenorhabditis elegans of Alzheimer's Model

Y Chen, Y Wang, Q Qin, Y Zhang, L Xie, J Xiao… - Food & Function, 2022 - pubs.rsc.org
Amyloid-β peptide (Aβ)-induced cholinergic system and mitochondrial dysfunction are major
risk factors for Alzheimer's disease (AD). Our previous studies found that carnosic acid (CA) …

D-pinitol ameliorated H2O2-induced oxidative damage in PC12 cells and prolonged the lifespan by IIS pathway in Caenorhabditis elegans

M Zhang, Z Xu, L Shao, J Wang, Z He, Y Jiang… - … and Physiology Part C …, 2023 - Elsevier
D-pinitol (DP) has been extensively regarded as the main active component of legumes for
anti-aging. In this study, we intended to explore the anti-aging mechanism of DP, utilizing …

Macrocycles and macrocyclization in anticancer drug discovery: Important pieces of the puzzle

C Zhang, F Liu, Y Zhang, C Song - European Journal of Medicinal …, 2024 - Elsevier
Increasing disease-related proteins have been identified as novel therapeutic targets.
Macrocycles are emerging as potential solutions, bridging the gap between conventional …

More than skin deep: cyclic peptides as wound healing and cytoprotective compounds

YCJ Lee, B Javdan, A Cowan, K Smith - Frontiers in Cell and …, 2023 - frontiersin.org
The prevalence and cost of wounds pose a challenge to patients as well as the healthcare
system. Wounds can involve multiple tissue types and, in some cases, become chronic and …

An evaluation study on screening, partial purification, and characterization of proteins and antioxidant peptides from two varieties of Clitoria Ternatea

S Harykrishnan, M Ganapathy, K Abinaya… - International Journal of …, 2025 - Elsevier
This study focused on the unexplored bioactive proteins derived from the flower of Clitoria
ternatea. The profiling of blue and white C. ternatea flowers was compared. After extraction …

Carnosol reduced pathogenic protein aggregation and cognitive impairment in neurodegenerative diseases models via improving proteostasis and ameliorating …

Y Chen, Q Qin, W Zhao, D Luo, Y Huang… - Journal of agricultural …, 2022 - ACS Publications
Neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease are incurable diseases with progressive loss of neural function and …

[HTML][HTML] New insights into involvement of low molecular weight proteins in complex defense mechanisms in higher plants

M Ruszczyńska, H Sytykiewicz - International Journal of Molecular …, 2024 - mdpi.com
Dynamic climate changes pose a significant challenge for plants to cope with numerous
abiotic and biotic stressors of increasing intensity. Plants have evolved a variety of …