Consensus paper: cerebellar development

K Leto, M Arancillo, EBE Becker, A Buffo, C Chiang… - The Cerebellum, 2016 - Springer
The development of the mammalian cerebellum is orchestrated by both cell-autonomous
programs and inductive environmental influences. Here, we describe the main processes of …

The cerebellar involvement in autism spectrum disorders: from the social brain to mouse models

L Mapelli, T Soda, E D'Angelo, F Prestori - International journal of …, 2022 - mdpi.com
Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that include
a variety of forms and clinical phenotypes. This heterogeneity complicates the clinical and …

Transcription factor RORα enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element

JA Hall, M Pokrovskii, L Kroehling, BR Kim, SY Kim… - Immunity, 2022 - cell.com
Summary T helper 17 (Th17) cells regulate mucosal barrier defenses but also promote
multiple autoinflammatory diseases. Although many molecular determinants of Th17 cell …

Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism

AM Jetten - Nuclear receptor signaling, 2009 - journals.sagepub.com
The last few years have witnessed a rapid increase in our knowledge of the retinoid-related
orphan receptors RORα,-β, and-γ (NR1F1-3), their mechanism of action, physiological …

Autism spectrum disorder and the cerebellum

EBE Becker, CJ Stoodley - International review of neurobiology, 2013 - Elsevier
The cerebellum has been long known for its importance in motor learning and coordination.
Recently, anatomical, clinical, and neuroimaging studies strongly suggest that the …

Cellular commitment in the developing cerebellum

H Marzban, MR Del Bigio, J Alizadeh… - Frontiers in cellular …, 2015 - frontiersin.org
The mammalian cerebellum is located in the posterior cranial fossa and is critical for motor
coordination and non-motor functions including cognitive and emotional processes. The …

[HTML][HTML] Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene …

AT Nguyen, TA Rauch, GP Pfeifer, VW Hu - The FASEB Journal, 2010 - ncbi.nlm.nih.gov
Autism is currently considered a multigene disorder with epigenetic influences. To
investigate the contribution of DNA methylation to autism spectrum disorders, we have …

Sex hormones in autism: androgens and estrogens differentially and reciprocally regulate RORA, a novel candidate gene for autism

T Sarachana, M Xu, RC Wu, VW Hu - PloS one, 2011 - journals.plos.org
Autism, a pervasive neurodevelopmental disorder manifested by deficits in social behavior
and interpersonal communication, and by stereotyped, repetitive behaviors, is inexplicably …

A developmental and genetic classification for midbrain-hindbrain malformations

AJ Barkovich, KJ Millen, WB Dobyns - Brain, 2009 - academic.oup.com
Advances in neuroimaging, developmental biology and molecular genetics have increased
the understanding of developmental disorders affecting the midbrain and hindbrain, both as …

Fetal exposure to valproic acid dysregulates the expression of autism-linked genes in the developing cerebellum

M Guerra, V Medici, R Weatheritt, V Corvino… - Translational …, 2023 - nature.com
Autism spectrum disorder (ASD) includes a set of highly heritable neurodevelopmental
syndromes characterized by social and communication impairment, repetitive behaviour …