Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that include a variety of forms and clinical phenotypes. This heterogeneity complicates the clinical and …
Summary T helper 17 (Th17) cells regulate mucosal barrier defenses but also promote multiple autoinflammatory diseases. Although many molecular determinants of Th17 cell …
AM Jetten - Nuclear receptor signaling, 2009 - journals.sagepub.com
The last few years have witnessed a rapid increase in our knowledge of the retinoid-related orphan receptors RORα,-β, and-γ (NR1F1-3), their mechanism of action, physiological …
The cerebellum has been long known for its importance in motor learning and coordination. Recently, anatomical, clinical, and neuroimaging studies strongly suggest that the …
The mammalian cerebellum is located in the posterior cranial fossa and is critical for motor coordination and non-motor functions including cognitive and emotional processes. The …
AT Nguyen, TA Rauch, GP Pfeifer, VW Hu - The FASEB Journal, 2010 - ncbi.nlm.nih.gov
Autism is currently considered a multigene disorder with epigenetic influences. To investigate the contribution of DNA methylation to autism spectrum disorders, we have …
T Sarachana, M Xu, RC Wu, VW Hu - PloS one, 2011 - journals.plos.org
Autism, a pervasive neurodevelopmental disorder manifested by deficits in social behavior and interpersonal communication, and by stereotyped, repetitive behaviors, is inexplicably …
Advances in neuroimaging, developmental biology and molecular genetics have increased the understanding of developmental disorders affecting the midbrain and hindbrain, both as …
M Guerra, V Medici, R Weatheritt, V Corvino… - Translational …, 2023 - nature.com
Autism spectrum disorder (ASD) includes a set of highly heritable neurodevelopmental syndromes characterized by social and communication impairment, repetitive behaviour …