Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

Toll-like receptors and inflammatory bowel disease

Y Lu, X Li, S Liu, Y Zhang, D Zhang - Frontiers in immunology, 2018 - frontiersin.org
Inflammatory bowel disease (IBD) is one relapsing and lifelong disease that affects millions
of patients worldwide. Increasing evidence has recently highlighted immune-system …

Toll‐like receptor polymorphism in host immune response to infectious diseases: A review

S Mukherjee, S Huda… - Scandinavian journal of …, 2019 - Wiley Online Library
Immunopolymorphism is considered as an important aspect behind the resistance or
susceptibility of the host to an infectious disease. Over the years, researchers have explored …

Toll-like receptors: regulators of the immune response in the human gut

H Hug, MH Mohajeri, G La Fata - Nutrients, 2018 - mdpi.com
Toll-like receptors (TLRs) are powerful molecular regulators by which the immune system
may “sense” the environment and protect the host from pathogens or endogenous threats. In …

Epidemiology of inflammatory bowel disease in India: the great shift east

S Kedia, V Ahuja - Inflammatory intestinal diseases, 2017 - karger.com
Background: Inflammatory bowel disease (IBD), once considered to be a Western disease,
is increasingly being reported from India and other Asian countries. The present review …

Stem cell-based therapies for inflammatory bowel disease

HM Zhang, S Yuan, H Meng, XT Hou, J Li… - International Journal of …, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic, relapsing disease that severely affects
patients' quality of life. The exact cause of IBD is uncertain, but current studies suggest that …

Mechanistic insight: linking cardiovascular complications of inflammatory bowel disease

H Kumarapperuma, R Wang, PJ Little… - Trends in Cardiovascular …, 2024 - Elsevier
Cardiovascular diseases (CVD) are the leading cause of mortality worldwide despite an
aggressive reduction of traditional cardiovascular risk factors. Underlying inflammatory …

Leucine rich repeat proteins: sequences, mutations, structures and diseases

N Matsushima, S Takatsuka, H Miyashita… - Protein and peptide …, 2019 - ingentaconnect.com
Mutations in the genes encoding Leucine Rich Repeat (LRR) containing proteins are
associated with over sixty human diseases; these include high myopia, mitochondrial …

Compartmentalized antimicrobial defenses in response to flagellin

A Vijayan, M Rumbo, C Carnoy, JC Sirard - Trends in microbiology, 2018 - cell.com
Motility is often a pathogenicity determinant of bacteria targeting mucosal tissues. Flagella
constitute the machinery that propels bacteria into appropriate niches. Besides motility, the …

Natural flavone tricin exerted anti-inflammatory activity in macrophage via NF-κB pathway and ameliorated acute colitis in mice

XX Li, SG Chen, GGL Yue, HF Kwok, JKM Lee… - Phytomedicine, 2021 - Elsevier
Background Ulcerative colitis is a subtype of inflammatory bowel disease, characterized by
relapsing inflammation in the gastrointestinal tract with limited treatment options. Previous …