Maintenance of homeostatic immune surveillance and development of effective adaptive
immune responses require precise regulation of spatial and temporal lymphocyte trafficking …

Dynamic localization of receptors and signaling molecules at the plasma membrane and
within intracellular vesicular compartments is crucial for T lymphocyte sensing …

Abstract Patients with Wiskott–Aldrich syndrome (WAS) lacking a human leukocyte antigen-
matched donor may benefit from gene therapy through the provision of gene-corrected …

Cytotoxic lymphocytes fight pathogens and cancer by forming immune synapses with
infected or transformed target cells and then secreting cytotoxic perforin and granzyme into …

Cytotoxic T lymphocytes (CTLs) kill by forming immunological synapses with target cells and
secreting toxic proteases and the pore-forming protein perforin into the intercellular space …

CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin
network to drive the polarized secretion of lytic granules, initiating target cell death during …

The actin cytoskeleton is composed of dynamic filament networks that build adaptable local
architectures to sustain nearly all cellular activities in response to a myriad of stimuli …

The WAVE regulatory complex (WRC) is crucial for assembly of the peripheral branched
actin network constituting one of the main drivers of eukaryotic cell migration. Here, we …

When migratory T cells encounter antigen‐presenting cells (APCs), they arrest and form
radially symmetric, stable intercellular junctions termed immunological synapses which …

Exocytosis of cytotoxic granules (CG) by lymphocytes is required for the elimination of
infected and malignant cells. Impairments in this process underly a group of diseases with …