Structural, molecular, and functional insights into Schlafen proteins
Schlafen (SLFN) genes belong to a vertebrate gene family encoding proteins with high
sequence homology. However, each SLFN is functionally divergent and differentially …
sequence homology. However, each SLFN is functionally divergent and differentially …
Restriction factors regulating human herpesvirus infections
MC Serrero, SR Paludan - Trends in Immunology, 2024 - cell.com
Herpesviruses are DNA viruses and the cause of diseases ranging from mild skin conditions
to severe brain diseases. Mammalian antiviral host defense comprises an array of …
to severe brain diseases. Mammalian antiviral host defense comprises an array of …
piRNA processing by a trimeric Schlafen-domain nuclease
N Podvalnaya, AW Bronkhorst, R Lichtenberger… - Nature, 2023 - nature.com
Transposable elements are genomic parasites that expand within and spread between
genomes. PIWI proteins control transposon activity, notably in the germline,. These proteins …
genomes. PIWI proteins control transposon activity, notably in the germline,. These proteins …
Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence
O Bustos, S Naik, G Ayers, C Casola… - Gene, 2009 - Elsevier
Genes of the Schlafen family, first discovered in mouse, are expressed in hematopoietic
cells and are involved in immune processes. Previous results showed that they are …
cells and are involved in immune processes. Previous results showed that they are …
The Schlafen family: complex roles in different cell types and virus replication
F Liu, P Zhou, Q Wang, M Zhang… - Cell biology …, 2018 - Wiley Online Library
The Schlafen (slfn) gene family members express broadly, but the research has mainly
focused on human slfn (h‐slfn) and mouse slfn (m‐slfn). The slfn members can be divided …
focused on human slfn (h‐slfn) and mouse slfn (m‐slfn). The slfn members can be divided …
[HTML][HTML] Expression and regulation of Schlafen (SLFN) family members in primary human monocytes, monocyte-derived dendritic cells and T cells
A Puck, R Aigner, M Modak, P Cejka, D Blaas… - Results in …, 2015 - Elsevier
Schlafen (SLFN/Slfn) family members have been investigated for their involvement in
fundamental cellular processes including growth regulation, differentiation and control of …
fundamental cellular processes including growth regulation, differentiation and control of …
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
Here we describe a previously unknown form of inherited immunodeficiency revealed by an
N-ethyl-N-nitrosourea–induced mutation called elektra. Mice homozygous for this mutation …
N-ethyl-N-nitrosourea–induced mutation called elektra. Mice homozygous for this mutation …
Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis
Background The ten mouse and six human members of the Schlafen (Slfn) gene family all
contain an AAA domain. Little is known of their function, but previous studies suggest roles …
contain an AAA domain. Little is known of their function, but previous studies suggest roles …
Subcellular localization of the Schlafen protein family
B Neumann, L Zhao, K Murphy, TJ Gonda - Biochemical and biophysical …, 2008 - Elsevier
Although the first members of the Schlafen gene family were first described almost 10 years
ago, the precise molecular/biochemical functions of the proteins they encode still remain …
ago, the precise molecular/biochemical functions of the proteins they encode still remain …
Schlafens can put viruses to sleep
ET Kim, MD Weitzman - Viruses, 2022 - mdpi.com
The Schlafen gene family encodes for proteins involved in various biological tasks, including
cell proliferation, differentiation, and T cell development. Schlafens were initially discovered …
cell proliferation, differentiation, and T cell development. Schlafens were initially discovered …