[HTML][HTML] Drug delivery systems for RNA therapeutics
RNA-based gene therapy requires therapeutic RNA to function inside target cells without
eliciting unwanted immune responses. RNA can be ferried into cells using non-viral drug …
eliciting unwanted immune responses. RNA can be ferried into cells using non-viral drug …
[HTML][HTML] Diagnostics for COVID-19: moving from pandemic response to control
Diagnostics have proven to be crucial to the COVID-19 pandemic response. There are three
major methods for the detection of SARS-CoV-2 infection and their role has evolved during …
major methods for the detection of SARS-CoV-2 infection and their role has evolved during …
[HTML][HTML] Human genetic and immunological determinants of critical COVID-19 pneumonia
Q Zhang, P Bastard, A Cobat, JL Casanova - Nature, 2022 - nature.com
SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …
The efficacy and effectiveness of the COVID-19 vaccines in reducing infection, severity, hospitalization, and mortality: a systematic review
I Mohammed, A Nauman, P Paul… - Human vaccines & …, 2022 - Taylor & Francis
With the relatively rapid development of the COVID-19 pandemic, vaccine development has
become crucial for limiting disease transmission. The accelerated growth in the approved …
become crucial for limiting disease transmission. The accelerated growth in the approved …
[HTML][HTML] Covid-19 breakthrough infections in vaccinated health care workers
M Bergwerk, T Gonen, Y Lustig, S Amit… - … England Journal of …, 2021 - Mass Medical Soc
Background Despite the high efficacy of the BNT162b2 messenger RNA vaccine against
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rare breakthrough …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rare breakthrough …
[HTML][HTML] Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces B cell
responses that continue to evolve for at least a year. During that time, memory B cells …
responses that continue to evolve for at least a year. During that time, memory B cells …
[HTML][HTML] A paper-based assay for the colorimetric detection of SARS-CoV-2 variants at single-nucleotide resolution
The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
highlighted the need for versatile diagnostic assays that can discriminate among emerging …
highlighted the need for versatile diagnostic assays that can discriminate among emerging …
[HTML][HTML] Neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine serum
K Uriu, I Kimura, K Shirakawa… - … England Journal of …, 2021 - Mass Medical Soc
Neutralization of the SARS-CoV-2 Mu Variant The mu variant of SARS-CoV-2 was 10.6
times as resistant to neutralization by serum samples obtained from persons who had …
times as resistant to neutralization by serum samples obtained from persons who had …
[HTML][HTML] Disentangling the relative importance of T cell responses in COVID-19: leading actors or supporting cast?
The rapid development of multiple vaccines providing strong protection from severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a major achievement …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a major achievement …
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing
in Africa over the past year has led to a major increase in the number of sequences that …
in Africa over the past year has led to a major increase in the number of sequences that …