Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Alcohol dehydrogenases (ADHs), which belong to the oxidoreductase superfamily, catalyze
the interconversion between alcohols and aldehydes or ketones with high stereoselectivity …

Green chemistry aims to minimize the environmental hazards of chemical processes and
their products. Ever since its introduction by Anastas,[1] this principle has inspired …

Ketoreductases are tools for the synthesis of chiral alcohols in industry. However, the low
activity of natural enzymes often restricts their use in industrial applications. On the basis of …

Biocatalysis is an enabling technology for chemists. Using isolated enzymes or whole cells
gives access to a broad range of selective transformations—often inaccessible with …

Production of enantiomerically pure molecules is of utmost importance in the pharma
industry. In this context, biocatalysis emerges as an alternative to conventional chemical …

Bioreduction of ketones with self-sufficient cofactor regeneration is green and sustainable for
the synthesis of chiral secondary alcohols. In this study, a novel alcohol dehydrogenase Cg …

Enantiopure halohydrins, which are important building blocks for pharmaceutical agents,
could be synthesized by biocatalytic reduction of α-halo ketones using ketoreductases. In …

The short‐and medium‐chain dehydrogenase/reductase superfamilies are responsible for
most chiral alcohol production in laboratories and industries. In nature, they participate in …

The use of purified and overexpressed alcohol dehydrogenases to synthesize enantiopure
fluorinated alcohols is shown. When the bioreductions were performed with ADH-A from …