Protein X-ray crystallography and drug discovery
L Maveyraud, L Mourey - Molecules, 2020 - mdpi.com
With the advent of structural biology in the drug discovery process, medicinal chemists
gained the opportunity to use detailed structural information in order to progress screening …
gained the opportunity to use detailed structural information in order to progress screening …
[HTML][HTML] 3D electron diffraction as an important technique for structure elucidation of metal-organic frameworks and covalent organic frameworks
Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) have emerged
as the most widely investigated classes of porous materials during the past two decades …
as the most widely investigated classes of porous materials during the past two decades …
Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology
Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-
CoV-2 infection is crucial for understanding immune protection and identifying targets for …
CoV-2 infection is crucial for understanding immune protection and identifying targets for …
[HTML][HTML] Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations
Antibodies elicited by infection accumulate somatic mutations in germinal centers that can
increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related …
increase affinity for cognate antigens. We analyzed 6 independent groups of clonally related …
Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 …
coronavirus that is responsible for the current pandemic of coronavirus disease 2019 …
[HTML][HTML] Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high …
S Xia, M Liu, C Wang, W Xu, Q Lan, S Feng, F Qi, L Bao… - Cell research, 2020 - nature.com
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in
Wuhan, China has posed a serious threat to global public health. To develop specific anti …
Wuhan, China has posed a serious threat to global public health. To develop specific anti …
[HTML][HTML] Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies
Coronaviruses make use of a large envelope protein called spike (S) to engage host cell
receptors and catalyze membrane fusion. Because of the vital role that these S proteins play …
receptors and catalyze membrane fusion. Because of the vital role that these S proteins play …
ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies
The coronavirus spike glycoprotein attaches to host receptors and mediates viral fusion.
Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that …
Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that …
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras (G12S)
Drugs that directly impede the function of driver oncogenes offer exceptional efficacy and a
therapeutic window. The recently approved mutant selective small-molecule cysteine …
therapeutic window. The recently approved mutant selective small-molecule cysteine …
Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models
HY Huang, HY Liao, X Chen, SW Wang… - Science Translational …, 2022 - science.org
A major challenge to end the pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is to develop a broadly protective vaccine that elicits long-term …
coronavirus 2 (SARS-CoV-2) is to develop a broadly protective vaccine that elicits long-term …