[HTML][HTML] Merkel cell carcinoma: epidemiology, prognosis, therapy and unmet medical needs

D Schadendorf, C Lebbé, A Zur Hausen… - European journal of …, 2017 - Elsevier
Merkel cell carcinoma (MCC) is a rare skin cancer that is associated with Merkel cell
polyomavirus infection in most cases. Incidence rates of MCC have increased in past …

Non-melanoma skin cancers: Biological and clinical features

M Cives, F Mannavola, L Lospalluti, MC Sergi… - International Journal of …, 2020 - mdpi.com
Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC), squamous cell
carcinoma (SCC) and Merkel cell carcinoma (MCC). These neoplasms are highly diverse in …

Merkel cell carcinoma, version 1.2018, NCCN clinical practice guidelines in oncology

CK Bichakjian, T Olencki, SZ Aasi, M Alam… - Journal of the National …, 2018 - jnccn.org
This selection from the NCCN Guidelines for Merkel Cell Carcinoma (MCC) focuses on
areas impacted by recently emerging data, including sections describing MCC risk factors …

[HTML][HTML] Three-year survival, correlates and salvage therapies in patients receiving first-line pembrolizumab for advanced Merkel cell carcinoma

P Nghiem, S Bhatia, EJ Lipson… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Merkel cell carcinoma (MCC) is an aggressive skin cancer associated with poor
survival. Programmed cell death-1 (PD-1) pathway inhibitors have shown high rates of …

A cornucopia of human polyomaviruses

JA DeCaprio, RL Garcea - Nature reviews Microbiology, 2013 - nature.com
During the past 6 years, focused virus hunting has led to the discovery of nine new human
polyomaviruses, including Merkel cell polyomavirus, which has been linked to Merkel cell …

Recurrence and mortality risk of Merkel cell carcinoma by cancer stage and time from diagnosis

AM McEvoy, K Lachance, DS Hippe, K Cahill… - JAMA …, 2022 - jamanetwork.com
Importance Merkel cell carcinoma (MCC) often behaves aggressively; however, disease-
recurrence data are not captured in national databases, and it is unclear what proportion of …

Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival

KG Paulson, JG Iyer, AR Tegeder… - Journal of Clinical …, 2011 - ascopubs.org
Purpose Merkel cell carcinoma (MCC) is a polyomavirus-associated skin cancer that is
frequently lethal and lacks established prognostic biomarkers. This study sought to identify …

Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus

SJ Rodig, J Cheng, J Wardzala… - The Journal of …, 2012 - Am Soc Clin Investig
A human polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens.
The Merkel cell polyomavirus (MCPyV) genome undergoes clonal integration into the host …

Merkel cell carcinoma: a virus-induced human cancer

Y Chang, PS Moore - Annual Review of Pathology: Mechanisms …, 2012 - annualreviews.org
Merkel cell polyomavirus (MCV) is the first polyomavirus directly linked to human cancer,
and its recent discovery helps to explain many of the enigmatic features of Merkel cell …

Epidemiology of Merkel cell polyomavirus infection and Merkel cell carcinoma

S Silling, A Kreuter, T Gambichler, T Meyer… - Cancers, 2022 - mdpi.com
Simple Summary Merkel cell polyomavirus (MCPyV) is a widespread virus that is present on
human skin. Infection occurs early in life, and up to 90% of adults have antibodies against …