In recent years, neutrophils have attracted increasing attention because of their cancer-
promoting effects. An elevated neutrophil-to-lymphocyte ratio is considered a prognostic …

Neutrophils are the frontline cells in response to microbial infections and are involved in a
range of inflammatory disorders in the body. In recent years, neutrophils have gained …

Chemokines are a group of about 50 chemotactic cytokines crucial for the migration of
immune system cells and tumor cells, as well as for metastasis. One of the 20 chemokine …

Simple Summary Tumor angiogenesis is one of the most critical steps in the progression of
cancer. Owing to its fundamental role in tumor growth and metastasis, tumor angiogenesis is …

Metastasis, a primary cause of death in patients with malignancies, is promoted by intrinsic
changes in both tumor and non-malignant cells in the tumor microenvironment (TME). As …

Activation of the aryl hydrocarbon receptor (AhR) through environmental exposure to
chemicals including polycyclic aromatic hydrocarbons (PAHs) and polychlorinated dibenzo …

Mounting experimental evidence from in vitro and in vivo animal studies points to an
essential role of the CXCL8-CXCR1/2 axis in neutrophils in the pathophysiology of …

The notion that neutrophils exist as a homogeneous population is being replaced with the
knowledge that neutrophils adopt different functional states. Neutrophils can have a pro …

Recent findings have modified our understanding of the roles of chemokine receptor CXCR2
and its ligands in cancer, inflammation, and immunity. Studies in Cxcr2 tissue-specific …

Neutrophils are the most abundant immune cell in the circulation of human and act as
gatekeepers to discard foreign elements that have entered the body. They are essential in …