Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

The long non-coding RNA (lncRNA) urothelial carcinoma-associated 1 (UCA1) has been
recently shown to be dysregulated, which plays an important role in the progression of …

Abstract Fibroblast growth factor (FGF) 2, FGF4, FGF7 and FGF20 are representative
paracrine FGFs binding to heparan-sulfate proteoglycan and fibroblast growth factor …

Patients with cholangiocarcinoma often present with locally advanced or metastatic disease.
There is a need for effective therapeutic strategies for advanced stage cholangiocarcinoma …

Since the discovery of insulin in 1921, protein therapeutics have become vital tools in the
treatment of diabetes mellitus. This heritage has been extended with the comparatively …

Cancer is one of the leading causes of human mortality globally; therefore, intensive efforts
have been made to seek new active drugs with improved anticancer efficacy. Indazole …

Metastasis is the predominant reason for high mortality of hepatocellular carcinoma (HCC)
patients. It is critical to explore the molecular mechanism underlying HCC metastasis. Here …

[(3S)‐3‐[4‐Amino‐3‐[2‐(3, 5‐dimethoxyphenyl) ethynyl]‐1H‐pyrazolo [3, 4‐d] pyrimidin‐1‐
yl]‐1‐pyrrolidinyl]‐2‐propen‐1‐one (TAS‐120) is an irreversible inhibitor of the fibroblast …

Dysregulation of Fibroblast Growth Factor Receptor (FGFR) signaling through amplifications,
mutations, and gene fusions has been implicated in a broad array of cancers (eg liver …