Interaction between Metformin, Folate and Vitamin B12 and the Potential Impact on Fetal Growth and Long-Term Metabolic Health in Diabetic Pregnancies

MD Owen, BC Baker, EM Scott, K Forbes - International journal of …, 2021 - mdpi.com
Metformin is the first-line treatment for many people with type 2 diabetes mellitus (T2DM)
and gestational diabetes mellitus (GDM) to maintain glycaemic control. Recent evidence …

Do nutrients and nutraceuticals play a role in diabetic retinopathy? A systematic review

A Milluzzo, M Barchitta, A Maugeri, R Magnano San Lio… - Nutrients, 2022 - mdpi.com
Diabetic retinopathy (DR) is a multifactorial neuro-microvascular disease, whose prevalence
ranges from 25% to 60% of subjects affected by diabetes mellitus, representing the main …

Associations of serum folate and vitamin B12 levels with cardiovascular disease mortality among patients with type 2 diabetes

Y Liu, T Geng, Z Wan, Q Lu, X Zhang, Z Qiu… - JAMA network …, 2022 - jamanetwork.com
Importance The associations of serum folate and vitamin B 12 levels with cardiovascular
outcomes among patients with type 2 diabetes (T2D) remain unclear. Objective To …

Multiomic patterns in body fluids: technological challenge with a great potential to implement the advanced paradigm of 3P medicine

C Gerner, V Costigliola… - Mass spectrometry …, 2020 - Wiley Online Library
Liquid biopsy (LB) is defined as a sample of any of body fluids (blood, saliva, tear fluid,
urine, sweat, amniotic, cerebrospinal and pleural fluids, cervicovaginal secretion, and …

DNA methylation in diabetic retinopathy: pathogenetic role and potential therapeutic targets

C Cai, C Meng, S He, C Gu, T Lhamo, D Draga, D Luo… - Cell & Bioscience, 2022 - Springer
Background Diabetic retinopathy (DR), a specific neuron-vascular complication of diabetes,
is a major cause of vision loss among middle-aged people worldwide, and the number of …

Folate and retinal vascular diseases

J Gu, C Lei, M Zhang - BMC ophthalmology, 2023 - Springer
Folate, a pteroylglutamic acid derivative, participates in fundamental cellular metabolism.
Homocysteine, an amino acid, serves as an intermediate of the methionine cycle and can be …

Circulating biomarkers of diabetic retinopathy: an overview based on physiopathology

O Simó-Servat, R Simó… - Journal of Diabetes …, 2016 - Wiley Online Library
Diabetic retinopathy (DR) is the main cause of working‐age adult‐onset blindness. The
currently available treatments for DR are applicable only at advanced stages of the disease …

Molecular markers of diabetic retinopathy: potential screening tool of the future?

P Pusparajah, LH Lee, K Abdul Kadir - Frontiers in physiology, 2016 - frontiersin.org
Diabetic retinopathy (DR) is among the leading causes of new onset blindness in adults.
Effective treatment may delay the onset and progression of this disease provided it is …

Metformin and micronutrient status in type 2 diabetes: does polypharmacy involving acid-suppressing medications affect vitamin B12 levels?

M Wakeman, DT Archer - Diabetes, Metabolic Syndrome and …, 2020 - Taylor & Francis
Metformin is the first-choice drug in uncomplicated type 2 diabetes (T2DM) and is effective in
improving glycaemic control. It is the most widely prescribed oral antidiabetic medicine and …

Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 …

O Asbaghi, D Ashtary-Larky, R Bagheri… - Critical Reviews in …, 2022 - Taylor & Francis
Folic acid supplementation has received considerable attention in the literature, yet there is
a large discrepancy in its effects on lipid markers in adults. Therefore, this systematic review …