Liver fibrosis in biliary atresia

WJ Shen, G Chen, M Wang, S Zheng - World Journal of Pediatrics, 2019 - Springer
Background Biliary atresia (BA) is the most common cause of obstructive jaundice in infants.
Although the Kasai procedure has greatly improved the prognosis, most patients still need …

Biliary atresia animal models: Is the needle in a haystack?

N Pal, PS Joy, CM Sergi - International Journal of Molecular Sciences, 2022 - mdpi.com
Biliary atresia (BA) is a progressive fibro-obliterative process with a variable degree of
inflammation involving the hepatobiliary system. Its consequences are incalculable for the …

Identification of a plant isoflavonoid that causes biliary atresia

K Lorent, W Gong, KA Koo… - Science translational …, 2015 - science.org
Biliary atresia (BA) is a rapidly progressive and destructive fibrotic disorder of unknown
etiology affecting the extrahepatic biliary tree of neonates. Epidemiological studies suggest …

[PDF][PDF] The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17

O Waisbourd‐Zinman, H Koh, S Tsai, PM Lavrut… - …, 2016 - Wiley Online Library
Biliary atresia, the most common indication for pediatric liver transplantation, is a fibrotic
disease of unknown etiology affecting the extrahepatic bile ducts of newborns. The recently …

Staging of biliary atresia at diagnosis by molecular profiling of the liver

K Moyer, V Kaimal, C Pacheco, R Mourya, H Xu… - Genome Medicine, 2010 - Springer
Background Young age at portoenterostomy has been linked to improved outcome in biliary
atresia, but pre-existing biological factors may influence the rate of disease progression. In …

[HTML][HTML] Bile duct ligature in young rats: A revisited animal model for biliary atresia

M Garrido, C Escobar, C Zamora, C Rejas… - European journal of …, 2017 - ncbi.nlm.nih.gov
Biliary atresia leads to cirrhosis in the vast majority of patients and constitutes the first cause
of paediatric liver transplantation. Animal models allow us to understand the molecular basis …

Extrahepatic cholangiocyte cilia are abnormal in biliary atresia

S Karjoo, NJ Hand, L Loarca, PA Russo… - Journal of pediatric …, 2013 - journals.lww.com
Objectives: Biliary atresia (BA) is a rapidly progressive form of biliary fibrosis affecting
neonates. We previously reported that primary cilia on the intrahepatic cholangiocytes of …

Ultrastructural characteristics of rat hepatic oval cells and their intercellular contacts in the model of biliary fibrosis: new insights into experimental liver fibrogenesis

JM Lotowska, ME Sobaniec-Lotowska… - Gastroenterology …, 2017 - Wiley Online Library
Purpose. Recently, it has been emphasized that hepatic progenitor/oval cells (HPCs) are
significantly involved in liver fibrogenesis. We evaluated the multipotential population of …

Liquid chromatography–mass spectroscopy in the diagnosis of biliary atresia in children with hyperbilirubinemia

J Golden, JA Zagory, M Fenlon, CJ Goodhue… - Journal of Surgical …, 2018 - Elsevier
Background Biliary atresia (BA) is difficult to distinguish from other causes of cholestasis. We
evaluated the use of liquid chromatography–mass spectroscopy (LC-MS) and bile acid …

The sea lamprey as an etiological model for biliary atresia

YW Chung-Davidson, CY Yeh… - BioMed research …, 2015 - Wiley Online Library
Biliary atresia (BA) is a progressive, inflammatory, and fibrosclerosing cholangiopathy in
infants that results in obstruction of both extrahepatic and intrahepatic bile ducts. It is the …