Neurotransmitters and neuromodulators have a wide range of key roles throughout the
nervous system. However, their dynamics in both health and disease have been challenging …

Intensiometric genetically encoded biosensors, based on allosteric modulation of the
fluorescence of a single fluorescent protein, are powerful tools for enabling imaging of …

Genetically encoded dopamine sensors based on green fluorescent protein (GFP) enable
high-resolution imaging of dopamine dynamics in behaving animals. However, these GFP …

Recent progress in fluorescence imaging allows neuroscientists to observe the dynamics of
thousands of individual neurons, identified genetically or by their connectivity, across …

Interest in deciphering the fundamental mechanisms and processes of the human mind
represents a central driving force in modern neuroscience research. Activities in support of …

The electromechanical function of the heart involves complex, coordinated activity over time
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …

Recent advances in fluorescence imaging permit large-scale recording of neural activity and
dynamics of neurochemical release with unprecedented resolution in behaving animals …

We developed a flexible two-photon microendoscope (2P-FENDO) capable of all-optical
brain investigation at near cellular resolution in freely moving mice. The system performs fast …

While calcium imaging has become a mainstay of modern neuroscience, the spectral
properties of current fluorescent calcium indicators limit deep-tissue imaging as well as …

Functional imaging using fluorescent indicators has revolutionized biology, but additional
sensor scaffolds are needed to access properties such as bright, far-red emission. Here, we …