Over the past two decades, RNA interference has become an extensively studied
mechanism to silence gene and treat diseases including cancer. siRNA appears as a …

COL1A1 is an important extracellular matrix component that is associated with poor
prognosis in cancers. In this study, As1411 aptamer-conjugated liposomes were used for …

Abstract pH-sensitive drug carriers that are sensitive to the acidic (pH=~ 6.5)
microenvironments of tumor tissues have been primarily used as effective drug/gene/siRNA …

Numerous prior studies have been reported on the use of pH-sensitive drug carriers such as
micelles, liposomes, peptides, polymers, nanoparticles, etc. that are sensitive to the acidic …

The major disadvantage of cancer chemotherapy is its lack of specificity. In recent years,
selective delivery of chemotherapeutic agents to tumor sites has evolved rapidly in the form …

Three different malachite green leuco derivatives (MG-Xs) are incorporated in liposomes. In
all three cases, a substituent (X) is covalently linked to the central carbon atom, abbreviated …

Three groups of synthetic lipids are chosen for studies:(1) 1, 4‐dihydropyridines (1, 4‐DHPs)
containing two cationic moieties and their analogues;(2) 3, 4‐dihydro‐2 (1H)‐pyridones …

Diblock copolymers (mPEG‐b‐PDPA), which were designed to possess pH‐sensitivity as
well as amphipathy, were used as an intelligent lock in the liposomal membrane. The so …

The rational design of particle-based cancer theranostic agents, combining diagnostic and
therapeutic features in a single entity, has emerged as an effective approach toward …

Background: Histone deacetylases (HDACs) are the enzymes that catalyze the removal of
the acetyl group from lysine residues and regulate several biological processes …