The study aims to discuss the effects of aging on the male reproductive system. A systematic
review was performed using PubMed from 1980 to 2014. Aging is a natural process …

Advanced paternal age (APA) is associated with infertility and other reproductive risks.
Studies looking at APA and outcomes have used different paternal age cut‐offs, which has …

All genetic variation arises via new mutations; therefore, determining the rate and biases for
different classes of mutation is essential for understanding the genetics of human disease …

The fundamental underlying paradigm of sexual reproduction is the production of male and
female gametes of sufficient genetic difference and quality that, following syngamy, they …

Using array comparative genome hybridisation (CGH) 41 de novo reciprocal translocations
and 18 de novo complex chromosome rearrangements (CCRs) were screened. All cases …

BACKGROUND Complex chromosomal rearrangements (CCRs) describe structural
rearrangements, essentially translocations, involving at least three breakpoints on two or …

Background De novo mutations and structural rearrangements are a common cause of
intellectual disability (ID) and other disorders with reduced or null reproductive fitness …

The process of aging refers to physiological changes that occur to an organism as time
progresses and involves changes to DNA, proteins, metabolism, cells, and organs. Like the …

Velocardiofacial and DiGeorge syndromes, also known as 22q11. 2 deletion syndrome
(22q11DS), are congenital-anomaly disorders caused by a de novo hemizygous 22q11. 2 …

Paternal age at conception has been increasing. In this review, we first present the results
from the major mammalian animal models used to establish that increasing paternal age …