A field guide to flow chemistry for synthetic organic chemists

L Capaldo, Z Wen, T Noël - Chemical science, 2023 - pubs.rsc.org
Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea
that it is a mysterious “black box” needs to go. In this review, we show that several of the …

An outlook on microfluidics: the promise and the challenge

S Battat, DA Weitz, GM Whitesides - Lab on a Chip, 2022 - pubs.rsc.org
This perspective considers ways in which the field of microfluidics can increase its impact by
improving existing technologies and enabling new functionalities. We highlight applications …

Expanding the medicinal chemistry synthetic toolbox

J Boström, DG Brown, RJ Young… - Nature Reviews Drug …, 2018 - nature.com
The key objectives of medicinal chemistry are to efficiently design and synthesize bioactive
compounds that have the potential to become safe and efficacious drugs. Most medicinal …

How to approach flow chemistry

M Guidi, PH Seeberger, K Gilmore - Chemical Society Reviews, 2020 - pubs.rsc.org
Flow chemistry is a widely explored technology whose intrinsic features both facilitate and
provide reproducible access to a broad range of chemical processes that are otherwise …

The hitchhiker's guide to flow chemistry∥

MB Plutschack, B Pieber, K Gilmore… - Chemical …, 2017 - ACS Publications
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …

Microfluidics for drug development: from synthesis to evaluation

Y Liu, L Sun, H Zhang, L Shang, Y Zhao - Chemical reviews, 2021 - ACS Publications
Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

Progress in microfluidics‐based exosome separation and detection technologies for diagnostic applications

S Lin, Z Yu, D Chen, Z Wang, J Miao, Q Li, D Zhang… - Small, 2020 - Wiley Online Library
Exosomes are secreted by most cell types and circulate in body fluids. Recent studies have
revealed that exosomes play a significant role in intercellular communication and are closely …

Microfluidic electrochemistry for single-electron transfer redox-neutral reactions

Y Mo, Z Lu, G Rughoobur, P Patil, N Gershenfeld… - Science, 2020 - science.org
Electrochemistry offers opportunities to promote single-electron transfer (SET) redox-neutral
chemistries similar to those recently discovered using visible-light photocatalysis but without …

Interplay between materials and microfluidics

X Hou, YS Zhang, GT Santiago, MM Alvarez… - Nature Reviews …, 2017 - nature.com
Developments in the field of microfluidics have triggered technological revolutions in many
disciplines, including chemical synthesis, electronics, diagnostics, single-cell analysis, micro …

Continuous flow chemistry: where are we now? Recent applications, challenges and limitations

FM Akwi, P Watts - Chemical communications, 2018 - pubs.rsc.org
A general outlook of the changing face of chemical synthesis is provided in this article
through recent applications of continuous flow processing in both industry and academia …