Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it

K Begriche, A Igoudjil, D Pessayre, B Fromenty - Mitochondrion, 2006 - Elsevier
Calorie-enriched diet and lack of exercise are causing a worldwide surge of obesity, insulin
resistance and lipid accretion in liver (ie hepatic steatosis), which can lead to steatohepatitis …

Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease

KG Tolman, V Fonseca, A Dalpiaz, MH Tan - Diabetes care, 2007 - Am Diabetes Assoc
METHODS—A Medline search without limitations of date (as of October 2005), language, or
humans was carried out by the authors. The following medical subject headings were …

Nonalcoholic fatty liver disease

LA Adams, P Angulo, KD Lindor - Cmaj, 2005 - Can Med Assoc
NONALCOHOLIC FATTY LIVER DISEASE is emerging as the most common chronic liver
condition in the Western world. It is associated with insulin resistance and frequently occurs …

[PDF][PDF] High‐dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis: a double‐blind, randomized, placebo‐controlled trial

UFH Leuschner, B Lindenthal, G Herrmann… - …, 2010 - Wiley Online Library
In uncontrolled clinical studies, ursodeoxycholic acid (UDCA) had a beneficial effect on
nonalcoholic steatohepatitis (NASH). However, a large controlled trial using UDCA (13‐15 …

Dyslipidemia in patients with nonalcoholic fatty liver disease

H Chatrath, R Vuppalanchi… - Seminars in liver …, 2012 - thieme-connect.com
Patients with nonalcoholic fatty liver disease (NAFLD) often have dyslipidemia along with
other features of metabolic syndrome such as obesity, diabetes mellitus, and hypertension …

Nonalcoholic fatty liver disease: a review and update

JR Lewis, SR Mohanty - Digestive diseases and sciences, 2010 - Springer
The spectrum of nonalcoholic fatty liver disease (NAFLD) ranges from asymptomatic
steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Hepatic steatosis occurs …

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

F Caballero, A Fernández, AM De Lacy… - Journal of …, 2009 - Elsevier
BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) pathogenesis remains
unknown. Due to the emerging role of free cholesterol (FC) in NAFLD, our aim was to …

Treatment of non-alcoholic fatty liver disease

LA Adams, P Angulo - Postgraduate medical journal, 2006 - academic.oup.com
Non-alcoholic fatty liver disease (NAFLD) is common and may progress to cirrhosis and its
complications. The pathogenesis of steatosis and cellular injury is thought to be related …

Atorvastatin and antioxidants for the treatment of nonalcoholic fatty liver disease: the St Francis Heart Study randomized clinical trial

T Foster, MJ Budoff, S Saab, N Ahmadi… - Official journal of the …, 2011 - journals.lww.com
OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) is defined as the spectrum of benign
fatty liver to necroinflammation and fibrosis. Its prevalence has been found to be as high as …

Non‐alcoholic fatty liver disease from pathogenesis to management: an update

G Musso, R Gambino, M Cassader - Obesity Reviews, 2010 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in the
Western world, is tightly associated with obesity and metabolic syndrome. NAFLD entails an …