[HTML][HTML] A review of the recent development in the synthesis and biological evaluations of pyrazole derivatives
O Ebenezer, M Shapi, JA Tuszynski - Biomedicines, 2022 - mdpi.com
Pyrazoles are five-membered heterocyclic compounds that contain nitrogen. They are an
important class of compounds for drug development; thus, they have attracted much …
important class of compounds for drug development; thus, they have attracted much …
Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
Molecular spectroscopy evidence of 1, 3, 5-tris (4-carboxyphenyl) benzene binding to DNA: anticancer potential along with the comparative binding profile of …
One of medicinal chemistry's top priorities is the discovery of new molecules with anticancer
potential. Compounds that interact with DNA are an intriguing family of chemotherapeutic …
potential. Compounds that interact with DNA are an intriguing family of chemotherapeutic …
Design, synthesis, anticancer activity and docking studies of novel quinazoline-based thiazole derivatives as EGFR kinase inhibitors
The in vitro anticancer efficacy of a new series of quinazoline-based thiazole derivatives was
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
explored. Three cancer cell lines, MCF-7, HepG2, and A548, as well as the normal Vero cell …
Experimental and theoretical examinations of triazole linked saccharin derivatives as organic corrosion inhibitors for mild steel in hydrochloric acid
The new triazole linked saccharin derivatives namely, 2-(3-methyl-1H-1, 2, 4-triazol-5-yl)
benzo [d] isothiazol-3 (2H)-one 1, 1-dioxide (MTD) and 2-(3-isopropyl-1H-1, 2, 4-triazol-5-yl) …
benzo [d] isothiazol-3 (2H)-one 1, 1-dioxide (MTD) and 2-(3-isopropyl-1H-1, 2, 4-triazol-5-yl) …
Design, synthesis, anticancer activity and molecular docking of novel 1H-benzo [d] imidazole derivatives as potential EGFR inhibitors
CE Theodore, G Sivaiah, SBB Prasad… - Journal of Molecular …, 2023 - Elsevier
Here, we present the design, synthesis, and evaluation of a new series of 1H-benzo [d]
imidazole derivatives (10a–j) to determine their anticancer efficacy. The MCF-7 and HCT116 …
imidazole derivatives (10a–j) to determine their anticancer efficacy. The MCF-7 and HCT116 …
Antitumor activity of s-triazine derivatives: a systematic review
Q Dai, Q Sun, X Ouyang, J Liu, L Jin, A Liu, B He, T Fan… - Molecules, 2023 - mdpi.com
1, 3, 5-triazine derivatives, also called s-triazines, are a series of containing-nitrogen
heterocyclic compounds that play an important role in anticancer drug design and …
heterocyclic compounds that play an important role in anticancer drug design and …
Design and synthesis of novel benzimidazole linked thiazole derivatives as promising inhibitors of drug-resistant tuberculosis
Despite combination therapy is effective in treating tuberculosis (TB) caused by susceptible
Mycobacterium tuberculosis (Mtb) strains, overcoming multidrug resistance (MDR) remains …
Mycobacterium tuberculosis (Mtb) strains, overcoming multidrug resistance (MDR) remains …
Synthesis, spectral analysis, DFT calculations, biological potential and molecular docking studies of indole appended pyrazolo-triazine
Abstract A series of novel 5-(3, 5-disubstituted-1 H-indol-2-yl)-2, 3-dimethyl-1-phenyl-2, 6-
dihydro-1 H-pyrazolo [4, 3-e][1, 2, 4] triazines (3a-l) were synthesized in single step from 3, 5 …
dihydro-1 H-pyrazolo [4, 3-e][1, 2, 4] triazines (3a-l) were synthesized in single step from 3, 5 …
Designing strategies, structural activity relationship and biological activity of recently developed nitrogen containing heterocyclic compounds as epidermal growth …
Cancer cells have the ability of dysregulation and autonomous proliferation due to
unchecked production of definite molecules. These molecules are involved in the cell growth …
unchecked production of definite molecules. These molecules are involved in the cell growth …