Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and
luminal exposures but converge on a shared transcriptional program, including expression …

Background and aims Molecular evidence of cellular heterogeneity in the human exocrine
pancreas has not been yet established, due to the local concentration and cascade of …

Background & Aims Acinar to ductal metaplasia (ADM) occurs in the pancreas in response
to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies …

Although tuft cells were discovered over 60 years ago, their functions have long been
enigmatic, especially in human health. Nonetheless, tuft cells have recently emerged as key …

During development of pancreatic cancer macrophage-mediated inflammatory processes
and the formation of cancerous lesions are tightly connected. Based on insight from mouse …

Tuft cells are chemosensory epithelial cells that increase in number following infection or
injury to robustly activate the innate immune response to alleviate or promote disease …

While the lung bears significant regenerative capacity, severe viral pneumonia can
chronically impair lung function by triggering dysplastic remodeling. The connection …

Background Tuft cells are chemosensory epithelial cells playing a role in innate immunity.
Recent studies revealed cancers with a tuft cell-like gene expression signature in the thorax …

Tuft cells are a rare and morphologically distinct chemosensory cell type found throughout
many organs, including the gastrointestinal tract. These cells were identified by their unique …