There is substantial epidemiological and experimental evidence of an obesity-related
asthma phenotype. Compared to children of healthy weight, children with obesity are at …

Allergists and clinical immunologists around the world are increasingly faced with the task of
addressing drug allergy and hypersensitivity due to the increase in drug reactions …

Non‐T2 asthma is traditionally defined as asthma without features of T2 asthma. The
definition is arbitrary and is generally based on the presence of neutrophils in sputum, or the …

Objective. Patients with severe asthma respond poorly to corticosteroids, and their care
accounts for more than 60% of the total costs attributed to asthma. Neutrophils form …

The incidence of allergic disease has grown tremendously in the past three generations.
While current treatments are effective for some, there is considerable unmet need. Mast cells …

Background Statins, which are a type of 3-hydroxy-3-methylglutaryl-CoA inhibitor, have
multiple therapeutic effects, including anti-inflammatory and immunomodulatory properties …

The efficacy of rosuvastatin in reducing allergic inflammation has been established.
However, its potential to reduce airway remodeling has yet to be explored. This study aimed …

IgE-mediated mast cell activation is a driving force in allergic disease in need of novel
interventions. Statins, long used to lower serum cholesterol, have been shown in multiple …

The field of sterol and oxysterol biology in lung disease has recently gained attention,
revealing a unique need for sterol uptake and metabolism in the lung. The presence of …

While sterols regulate immune processes key to the pathogenesis of asthma, inhibition of
sterols with statin drugs has shown conflicting results in human asthma. Here, a novel …