Next-generation sequencing (NGS) technologies are increasingly being used to address a
diverse range of biological and epidemiological questions. The current understanding of …

Molecular approaches have an increasingly recognized utility in surveillance of malaria
parasite populations, not only in defining prevalence and incidence with higher sensitivity …

Local and cross-border importation remain major challenges to malaria elimination and are
difficult to measure using traditional surveillance data. To address this challenge, we …

Malaria results in over 600,000 deaths annually, with the highest burden of deaths in young
children living in sub-Saharan Africa. Molecular surveillance can provide important …

With the rapidly increasing abundance and accessibility of genomic data, there is a growing
interest in using population genetic approaches to characterize fine-scale dispersal of …

Pathogen control programs provide a valuable, but rarely exploited, opportunity to directly
examine the relationship between population decline and population genetics. We …

Controlled human malaria infection (CHMI) by mosquito bite has been used to assess anti-
malaria interventions in> 1,500 volunteers since development of methods for infecting …

As many malaria-endemic countries move towards elimination of Plasmodium falciparum,
the most virulent human malaria parasite, effective tools for monitoring malaria epidemiology …

Locally varying selection on pathogens may be due to differences in drug pressure, host
immunity, transmission opportunities between hosts, or the intensity of between-genotype …

Background Recent global progress in scaling up malaria control interventions has revived
the goal of complete elimination in many countries. Decreasing transmission intensity …