[HTML][HTML] Streptozotocin as a tool for induction of rat models of diabetes: A practical guide

A Ghasemi, S Jeddi - EXCLI journal, 2023 - ncbi.nlm.nih.gov
Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type
1 and type 2 diabetes. Despite~ 60 years of using STZ in animal diabetes research, some …

Aloe vera and Streptozotocin-Induced Diabetes Mellitus

F Haghani, MR Arabnezhad, S Mohammadi… - Revista Brasileira de …, 2022 - Springer
Diabetes mellitus is defined as prolonged hyperglycemia, which can harm the eyes, kidneys,
and cardiovascular and neurological systems. Herbal agents and their derived supplements …

Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways

H Tan, J Chen, Y Li, Y Li, Y Zhong, G Li, L Liu, Y Li - Molecular Medicine, 2022 - Springer
Abstract Background Glabridin (Glab) is a bioactive component of licorice that can
ameliorate diabetes, but its role in diabetic nephropathy (DN) has seldom been reported …

[HTML][HTML] Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance

D Gerace, Q Zhou, JHR Kenty, A Veres, E Sintov… - Cell Reports …, 2023 - cell.com
Immunological protection of transplanted stem cell-derived islet (SC-islet) cells is yet to be
achieved without chronic immunosuppression or encapsulation. Existing genetic …

Moringa oleifera Leaf Extract Promotes Healing of Infected Wounds in Diabetic Rats: Evidence of Antimicrobial, Antioxidant and Proliferative Properties

AA Al-Ghanayem, MS Alhussaini, M Asad, B Joseph - Pharmaceuticals, 2022 - mdpi.com
Moringa oleifera is known to possess wound healing activity. The present study evaluated
the healing properties of methanolic extract of M. oleifera leaves in excision wounds infected …

Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas

K Hrovatin, A Bastidas-Ponce, M Bakhti, L Zappia… - Nature …, 2023 - nature.com
Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

Dysregulated CD200-CD200R signaling in early diabetes modulates microglia-mediated retinopathy

CW Pfeifer, JT Walsh, A Santeford… - Proceedings of the …, 2023 - National Acad Sciences
Diabetic retinopathy (DR) is a neurovascular complication of diabetes. Recent investigations
have suggested that early degeneration of the neuroretina may occur prior to the …

Guidelines on models of diabetic heart disease

LC Heather, AD Hafstad, GV Halade… - American Journal …, 2022 - journals.physiology.org
Diabetes is a major risk factor for cardiovascular diseases, including diabetic
cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular …

Animal models to study cardiac arrhythmias

DJ Blackwell, J Schmeckpeper… - Circulation research, 2022 - Am Heart Assoc
Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

[HTML][HTML] The effects of Bifidobacterium probiotic supplementation on blood glucose: A systematic review and meta-analysis of preclinical animal models and clinical …

EP Van Syoc, J Damani, Z DiMattia, E Ganda… - Advances in …, 2023 - Elsevier
Probiotic supplementation is a potential therapeutic for metabolic diseases including
obesity, metabolic syndrome (MetS), and Type 2 diabetes (T2D), but most studies deliver …