Giardia duodenalis flavohemoglobin is a target of 5-nitroheterocycle and benzimidazole compounds acting as enzymatic inhibitors or subversive substrates
EO Pech-Santiago, R Argüello-García… - Free Radical Biology …, 2025 - Elsevier
Giardia duodenalis causes giardiasis in humans, companion, livestock and wild animals.
Control of infection involves drugs as benzimidazoles (eg, albendazole, ABZ) and 5 …
Control of infection involves drugs as benzimidazoles (eg, albendazole, ABZ) and 5 …
Nitrosative Stress Response in Vibrio cholerae: Role of S-Nitrosoglutathione Reductase
Vibrio cholerae, the causative agent of cholera, poses serious threats to humans worldwide.
V. cholerae faces host inflammatory response and encounters nitrosative stress before …
V. cholerae faces host inflammatory response and encounters nitrosative stress before …
Quinones and nitroaromatic compounds as subversive substrates of Staphylococcus aureus flavohemoglobin
M Moussaoui, L Misevičienė, Ž Anusevičius… - Free Radical Biology …, 2018 - Elsevier
In microorganisms, flavohemoglobins (FHbs) containing FAD and heme (Fe 3+, metHb)
convert NO. into nitrate at the expense of NADH and O 2. FHbs contribute to bacterial …
convert NO. into nitrate at the expense of NADH and O 2. FHbs contribute to bacterial …
Impact of azole drugs on energetics, kinetics, and ligand migration pathways of CO photo-dissociation in bacterial flavohemoglobins
D Butcher, M Moussaoui, L Baciou, J Miksovska - RSC advances, 2020 - pubs.rsc.org
Flavohemoglobins (fHbs) are heme proteins found in prokaryotic and eukaryotic microbes.
They are involved in NO detoxification through an NO˙ dioxygenase mechanism. The N …
They are involved in NO detoxification through an NO˙ dioxygenase mechanism. The N …
Thermodynamics and Kinetics of Ligand Photodissociation in Heme Proteins and Formation of DNA i-Motif
DS Butcher - 2017 - digitalcommons.fiu.edu
Heme proteins carry out a diverse array of functions in vivo while maintaining a well-
conserved 3-over-3 α-helical structure. Human hemoglobin (Hb) is well-known for its oxygen …
conserved 3-over-3 α-helical structure. Human hemoglobin (Hb) is well-known for its oxygen …