Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Rationale: Despite increasing prevalence and incidence of heart failure (HF), therapeutic
options remain limited. In early stages of HF, sudden cardiac death (SCD) from ventricular …

Today, proteomics usually compares clinical samples by use of bottom-up profiling with high
resolution mass spectrometry, where all protein products of a single gene are considered as …

Age-related cognitive decline occurs without frank neurodegeneration and is the most
common cause of memory impairment in aging individuals. With increasing longevity …

Purpose: Targeting of the HER2 protein in human breast cancer represents a major advance
in oncology but relies on measurements of total HER2 protein and not HER2 signaling …

Background Tumor initiating stem-like cells (TISCs) are a subset of neoplastic cells that
possess distinct survival mechanisms and self-renewal characteristics crucial for tumor …

Background There is an urgent need to measure phosphorylated cell signaling proteins in
cancer tissue for the individualization of molecular targeted kinase inhibitor therapy …

Posttranslational modifications and proteolytic processing regulate almost all physiological
processes. Dysregulation can potentially result in pathologic protein species causing …

Solid carbon dioxide, also known as dry ice, is extensively used in various applications,
such as cleaning large telescopes, refrigeration, spray cooling, and biological processes like …

J. Neurochem.(2012) 121, 77–98. Abstract Impairment of cognitive functions including
hippocampus‐dependent spatial learning and memory affects nearly half of the aged …