Molecular and cellular insights into T cell exhaustion
EJ Wherry, M Kurachi - Nature reviews immunology, 2015 - nature.com
In chronic infections and cancer, T cells are exposed to persistent antigen and/or
inflammatory signals. This scenario is often associated with the deterioration of T cell …
inflammatory signals. This scenario is often associated with the deterioration of T cell …
Regulation of the immune response by TGF-β: from conception to autoimmunity and infection
Transforming growth factor β (TGF-β) is a pleiotropic cytokine involved in both suppressive
and inflammatory immune responses. After 30 years of intense study, we have only begun to …
and inflammatory immune responses. After 30 years of intense study, we have only begun to …
TGF-β regulates the stem-like state of PD-1+ TCF-1+ virus-specific CD8 T cells during chronic infection
Recent studies have defined a novel population of PD-1+ TCF-1+ stem-like CD8 T cells in
chronic infections and cancer. These quiescent cells reside in lymphoid tissues, are critical …
chronic infections and cancer. These quiescent cells reside in lymphoid tissues, are critical …
CD8+ T cell exhaustion
M Kurachi - Seminars in immunopathology, 2019 - Springer
CD8+ T cells are important for the protective immunity against intracellular pathogens and
tumor. In the case of chronic infection or cancer, CD8+ T cells are exposed to persistent …
tumor. In the case of chronic infection or cancer, CD8+ T cells are exposed to persistent …
Transforming growth factor-β signaling controls the formation and maintenance of gut-resident memory T cells by regulating migration and retention
N Zhang, MJ Bevan - Immunity, 2013 - cell.com
Tissue-resident memory T (Trm) cells represent a population of memory CD8+ T cells that
can act as first responders to local infection. The mechanisms regulating the formation and …
can act as first responders to local infection. The mechanisms regulating the formation and …
[HTML][HTML] Costimulatory and coinhibitory receptor pathways in infectious disease
J Attanasio, EJ Wherry - Immunity, 2016 - cell.com
Costimulatory and inhibitory receptors play a key role in regulating immune responses to
infections. Recent translation of knowledge about inhibitory receptors such as CTLA-4 and …
infections. Recent translation of knowledge about inhibitory receptors such as CTLA-4 and …
Principles of immunotherapy: implications for treatment strategies in cancer and infectious diseases
The advances in cancer biology and pathogenesis during the past two decades, have
resulted in immunotherapeutic strategies that have revolutionized the treatment of …
resulted in immunotherapeutic strategies that have revolutionized the treatment of …
Innate and adaptive immune regulation during chronic viral infections
EI Zuniga, M Macal, GM Lewis… - Annual review of …, 2015 - annualreviews.org
Chronic viral infections represent a unique challenge to the infected host. Persistently
replicating viruses outcompete or subvert the initial antiviral response, allowing the …
replicating viruses outcompete or subvert the initial antiviral response, allowing the …
OX40 stimulation and PD-L1 blockade synergistically augment HBV-specific CD4 T cells in patients with HBeAg-negative infection
FJ Jacobi, K Wild, M Smits, K Zoldan… - Journal of …, 2019 - Elsevier
Background & Aims Current antiviral therapies lack the potential to eliminate persistent
hepatitis B virus (HBV) infection. HBV-specific T cells are crucial for HBV control and have …
hepatitis B virus (HBV) infection. HBV-specific T cells are crucial for HBV control and have …
Molecular signatures of T-cell inhibition in HIV-1 infection
Cellular immune responses play a crucial role in the control of viral replication in HIV-
infected individuals. However, the virus succeeds in exploiting the immune system to its …
infected individuals. However, the virus succeeds in exploiting the immune system to its …