Research in the field of transfer RNA (tRNA) has undergone revolutionary changes in the
past few years. Although there has been a steady accumulation of chemical and biological …

The N7 position of guanine is the most nucleophilic site within the heterocyclic bases of DNA
(1). Accordingly, when double-stranded DNA is exposed to electrophiles, the predominant …

We present the theoretical and technical foundations of the Amsterdam Density Functional
(ADF) program with a survey of the characteristics of the code (numerical integration, density …

Empirical force‐field calculations on biological molecules represent an effective method to
obtain atomic detail information on the relationship of their structure to their function. Results …

Publisher Summary This chapter discusses the structure and function of DNA. DNA occupies
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …

Nucleic acidparameters are developed for the all-atomempirical energy function used in the
CHARMM program. The parameters were determined by use of results for model …

Up till now, there has been a significant disagreement between theory and experiment
regarding hydrogen bond lengths in Watson− Crick base pairs. To investigate the possible …

We challenge the view that the hydrogen bonds in Watson–Crick AT and GC base pairs are
in essence electrostatic interactions with substantial resonance assistance from the π …

The three-dimensional solution structure of a complex between the DNA binding domain of
the chicken erythroid transcription factor GATA-1 and its cognate DNA site has been …

Abstract Bradley et al.[(1972) Biopolymers11, 645–652] used electro-optical measurements
to show that methylene blue (MB), like acridine orange, in its DNA complex is oriented more …