The steroid hormone ecdysone is the central regulator of insect developmental transitions.
Recent new advances in our understanding of ecdysone action have relied heavily on the …

SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …

Monomethylation of histone H3 on Lys 4 (H3K4me1) and acetylation of histone H3 on Lys
27 (H3K27ac) are histone modifications that are highly enriched over the body of actively …

Kleefstra syndrome, caused by haploinsufficiency of euchromatin histone methyltransferase
1 (EHMT1), is characterized by intellectual disability (ID), autism spectrum disorder (ASD) …

Growth is a complex process that is intimately linked to the developmental program to form
adults with proper size and proportions. Genetics is an important determinant of growth, as …

The steroid hormone 20-hydroxyecdysone and its EcR/USP receptor are vital during
arthropod development for coordinating molting and metamorphosis. Traditionally, little …

The ecdysone pathway was among the first experimental systems employed to study the
impact of steroid hormones on the genome. In Drosophila and other insects, ecdysone …

Throughout the animal kingdom, steroid hormones have been implicated in the defense
against microbial infection, but how these systemic signals control immunity is unclear. Here …

Animals have a determined species-specific body size that results from the combined action
of hormones and signaling pathways regulating growth rate and duration. In Drosophila, the …

Hippo signaling limits organ growth by inhibiting the transcriptional coactivator Yorkie.
Despite the key role of Yorkie in both normal and oncogenic growth, the mechanism by …