It has long been recognized that an increase of reactive oxygen species (ROS) can modify
the cell‐signaling proteins and have functional consequences, which successively mediate …

Free radicals contain one or more unpaired electrons in their valence shell, thus making
them unstable, short-lived, and highly reactive species. Excessive generation of these free …

Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …

Accumulating evidence suggests that outdoor air pollution may have a significant impact on
central nervous system (CNS) health and disease. To address this issue, the National …

The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …

Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …

Metallothioneins (MTs) are a class of ubiquitously occurring low molecular mass, cysteine-
and metal-rich proteins containing sulfur-based metal clusters formed with Zn (II), Cd (II), and …

Synchrotron-based x-ray fluorescence microscopy, immunofluorescence, and Western
blotting were used to investigate changes in copper (Cu) and Cu-associated pathways in the …

Copper is a transition metal that has been linked to pathological and beneficial effects in
neurodegenerative diseases. In Parkinson's disease, free copper is related to increased …

Oxidative stress is a common hallmark of neuronal cell death associated with
neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as …