Spinocerebellar ataxias: prospects and challenges for therapy development

T Ashizawa, G Öz, HL Paulson - Nature Reviews Neurology, 2018 - nature.com
The spinocerebellar ataxias (SCAs) comprise more than 40 autosomal dominant
neurodegenerative disorders that present principally with progressive ataxia. Within the past …

Remote physical activity monitoring in neurological disease: a systematic review

VAJ Block, E Pitsch, P Tahir, BAC Cree, DD Allen… - PloS one, 2016 - journals.plos.org
Objective To perform a systematic review of studies using remote physical activity monitoring
in neurological diseases, highlighting advances and determining gaps. Methods Studies …

Real-life gait assessment in degenerative cerebellar ataxia: Toward ecologically valid biomarkers

W Ilg, J Seemann, M Giese, A Traschütz, L Schöls… - Neurology, 2020 - AAN Enterprises
Objectives With disease-modifying drugs on the horizon for degenerative ataxias,
ecologically valid motor biomarkers are highly warranted. In this observational study, we …

What adherence measures should be used in trials of home-based rehabilitation interventions? A systematic review of the validity, reliability, and acceptability of …

R Frost, S Levati, D McClurg, M Brady… - Archives of physical …, 2017 - Elsevier
Objective To systematically review methods for measuring adherence used in home-based
rehabilitation trials and to evaluate their validity, reliability, and acceptability. Data Sources …

Scales for the clinical evaluation of cerebellar disorders

K Bürk, DA Sival - Handbook of clinical Neurology, 2018 - Elsevier
Clinical scales represent an important tool not only for the initial grading/scoring of disease
and assessment of progression, but also for the quantification of therapeutic effects in …

Multimodal mobility assessment predicts fall frequency and severity in cerebellar ataxia

R Schniepp, A Huppert, J Decker, F Schenkel… - The Cerebellum, 2023 - Springer
This cohort study aims to evaluate the predictive validity of multimodal clinical assessment
and quantitative measures of in-and off-laboratory mobility for fall-risk estimation in patients …

Systematic literature review of abobotulinumtoxinA in clinical trials for lower limb spasticity

K Dashtipour, JJ Chen, HW Walker, MY Lee - Medicine, 2016 - journals.lww.com
Systematic Literature Review of AbobotulinumtoxinA in Clinic... : Medicine Systematic
Literature Review of AbobotulinumtoxinA in Clinical Trials for Lower Limb Spasticity : Medicine …

Psychometric properties of outcome measures evaluating decline in gait in cerebellar ataxia: a systematic review

SC Milne, A Murphy, N Georgiou-Karistianis, EM Yiu… - Gait & posture, 2018 - Elsevier
Cerebellar ataxia often results in impairment in ambulation secondary to gait pattern
dysfunction and compensatory gait adjustments. Pharmaceutical and therapy-based …

[HTML][HTML] Moving towards therapy in SCA1: insights from molecular mechanisms, identification of novel targets, and planning for human trials

SR Srinivasan, VG Shakkottai - Neurotherapeutics, 2019 - Elsevier
The spinocerebellar ataxias (SCAs) are a group of neurodegenerative disorders inherited in
an autosomal dominant fashion. The SCAs result in progressive gait imbalance …

Accelerometer-based measures in Friedreich ataxia: a longitudinal study on real-life activity

M Fichera, L Nanetti, A Monelli, A Castaldo… - Frontiers in …, 2024 - frontiersin.org
Quantitative measurement of physical activity may complement neurological evaluation and
provide valuable information on patients' daily life. We evaluated longitudinal changes of …