Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …

Tuberculosis is the leading infectious cause of death worldwide, with 9· 6 million cases and
1· 5 million deaths reported in 2014. WHO estimates 480 000 cases of these were multidrug …

How safe are autonomous vehicles? The answer is critical for determining how autonomous
vehicles may shape motor vehicle safety and public health, and for developing sound …

Purpose Real‐world evidence (RWE) includes data from retrospective or prospective
observational studies and observational registries and provides insights beyond those …

Studies that generate real-world evidence on the effects of medical products through
analysis of digital data collected in clinical practice provide key insights for regulators …

In alignment with the International Council of Harmonization's strategic goals, a public-
private consortium has developed a structured template for planning and reporting on the …

Regulators consider randomized controlled trials (RCTs) as the gold standard for evaluating
the safety and effectiveness of medications, but their costs, duration, and limited …

Untitled Page 1 Page 2 REALIST RESEARCH DOING Page 3 Sara Miller McCune founded
SAGE Publishing in 1965 to support the dissemination of usable knowledge and educate a …

The use of circulating cell-free DNA (cfDNA) as a biomarker in transplant recipients offers
advantages over invasive tissue biopsy as a quantitative measure for detection of transplant …

Highlights•Drug repositioning and similar terms have been a trending topic since
2004.•From a legal or regulatory perspective stimulation of drug repositioning requires …