Thousand and one kinases (TAOKs) are members of the MAP kinase kinase kinase
(MAP3K) family. Three members of this subfamily, TAOK1, 2, and 3, have been identified in …

The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling
and are essential for proper biological functions. Disruptions in this signaling axis can lead …

Atypical brain connectivity is a major contributor to the pathophysiology of
neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 …

Adolescent alcohol binge drinking constitutes a major vulnerability factor to develop
alcoholism. However, mechanisms underlying this susceptibility remain unknown. We …

Abnormalities in dendritic spines are manifestations of several neurodevelopmental and
psychiatric diseases. TAOK2 is one of the genes in the 16p11. 2 locus, copy number …

There are hundreds of risk genes associated with autism spectrum disorder (ASD), but
signaling networks at the protein level remain unexplored. We use neuron-specific proximity …

In this chapter, we review the effects of global null mutant and overexpressing transgenic
mouse lines on voluntary self-administration of alcohol. We examine approximately 200 …

Background Alcohol abuse and alcoholism are significant public health problems, but the
genetic basis for individual variation in alcohol sensitivity remains poorly understood …

Thousand and one amino acid kinases (TAOKs) are relatively understudied and functionally
pleiotropic protein kinases that have emerged as important regulators of neurodevelopment …

Neuronal signal transduction by the JNK MAP kinase pathway is altered by a broad array of
stimuli including exposure to the widely abused drug ethanol, but the behavioral relevance …