Studies in the past few years have provided compelling evidence for the critical role of
aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant …

There appear to be 2 pathways involved in the early pathogenesis of premalignant
monoclonal gammopathy of undetermined significance (MGUS) and malignant multiple …

Background and Aims Cancer‐associated fibroblasts (CAFs) are key players in multicellular,
stromal‐dependent alterations leading to HCC pathogenesis. However, the intricate …

Signal transducer and activator of transcription (STAT) proteins are latent cytoplasmic
transcription factors that were discovered in the context of cytokine and growth factor …

The pathogenetic mechanisms underlying the onset and the post-transplant recurrence of
primary focal segmental glomerulosclerosis (FSGS) are complex and remain yet to be fully …

Objectives To investigate the mechanism of Liuwei Dihuang Pill (六味地黄丸, LDP) in
treating postmenopausal osteoporosis (PMOP) with Shen (Kidney) yin deficiency. Methods …

Many factors such as vitamins, hormones and cytokines, control bone metabolism and
remodeling. Cytokines of the interleukin-6 family, by acting on bone cells (ie osteoblasts and …

Nerve fibers accompany blood and lymphatic vessels all over the body. An extensive
amount of knowledge has been obtained with regard to tumor angiogenesis and tumor …

The nervous system plays a central role in regulating the stem cell niche in many organs,
and thereby pivotally modulates development, homeostasis, and plasticity. A similarly …

Cancer-associated fibroblasts (CAF) have been reported to support tumor progression by a
variety of mechanisms. However, their role in the progression of non–small cell lung cancer …