The recent advances of glucosinolates and their metabolites: Metabolism, physiological functions and potential application strategies

J Wu, S Cui, J Liu, X Tang, J Zhao… - Critical reviews in …, 2023 - Taylor & Francis
Glucosinolates and their metabolites from Brassicaceae plants have received widespread
attention due to their anti-inflammatory effects. Glucosinolates occurs an “enterohepatic …

Molecular mechanisms of the anti-cancer effects of isothiocyanates from cruciferous vegetables in bladder cancer

T Mastuo, Y Miyata, T Yuno, Y Mukae, A Otsubo… - Molecules, 2020 - mdpi.com
Bladder cancer (BC) is a representative of urological cancer with a high recurrence and
metastasis potential. Currently, cisplatin-based chemotherapy and immune checkpoint …

Cruciferous vegetables, isothiocyanates, and prevention of bladder cancer

OL Veeranki, A Bhattacharya, L Tang… - Current pharmacology …, 2015 - Springer
Approximately 80% of human bladder cancers (BC) are non-muscle invasive when first
diagnosed and are usually treated by transurethral tumor resection. But 50–80% of patients …

Targeted therapies in bladder cancer: an overview of in vivo research

KEM Van Kessel, TCM Zuiverloon, AR Alberts… - Nature reviews …, 2015 - nature.com
Survival of patients with muscle-invasive bladder cancer is poor and new therapies are
needed. Currently, none of the targeted agents that are approved for cancer therapy have …

Inhibition of bladder cancer cell proliferation by allyl isothiocyanate (mustard essential oil)

ALV Sávio, GN da Silva, DMF Salvadori - Mutation Research/Fundamental …, 2015 - Elsevier
Natural compounds hold great promise for combating antibiotic resistance, the failure to
control some diseases, the emergence of new diseases and the toxicity of some …

Metastasis prevention: targeting causes and roots

AA Schegoleva, AA Khozyainova… - Clinical & Experimental …, 2022 - Springer
The spread of tumor cells from the primary focus, metastasis, is the main cause of cancer
mortality. Therefore, anticancer therapy should be focused on the prevention of metastatic …

Anticancer activity, mechanism, and delivery of allyl isothiocyanate

A Tarar, S Peng, S Cheema, CA Peng - Bioengineering, 2022 - mdpi.com
Allyl isothiocyanate (AITC) is a phytochemical that is abundantly present in cruciferous
vegetables of the Brassicaceae family, such as cabbage, broccoli, mustard, wasabi, and …

Chemoprevention with isothiocyanates–From bench to bedside

C Gründemann, R Huber - Cancer letters, 2018 - Elsevier
Isothiocyanates (ITCs) are naturally occurring hydrolization products from glucosinolates
(GLSs) in brassicaceae and in epidemiological studies their intake has been weakly to …

Design and synthesis of isothiocyanate‐containing hybrid androgen receptor (AR) antagonist to downregulate AR and induce ferroptosis in GSH–Deficient prostate …

Z Qin, S Ou, L Xu, K Sorensen, Y Zhang… - Chemical biology & …, 2021 - Wiley Online Library
Sustained androgen receptor (AR) signaling and apoptosis evasion are among the main
hurdles of castration‐resistant prostate cancer (CRPC) treatment. We designed and …

ERK-modulated intrinsic signaling and G2/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast …

SC Tsai, WW Huang, WC Huang… - International …, 2012 - spandidos-publications.com
Allyl isothiocyanate (AITC), a member of the isothiocyanate (ITC) family found in a
constituent of cruciferous vegetables, possesses anticancer activity and induces apoptosis …