Obesity and the risk of cardiometabolic diseases

PL Valenzuela, P Carrera-Bastos… - Nature reviews …, 2023 - nature.com
The prevalence of obesity has reached pandemic proportions, and now approximately 25%
of adults in Westernized countries have obesity. Recognized as a major health concern …

Lifestyle interventions for the prevention and treatment of hypertension

PL Valenzuela, P Carrera-Bastos, BG Gálvez… - Nature Reviews …, 2021 - nature.com
Hypertension affects approximately one third of the world's adult population and is a major
cause of premature death despite considerable advances in pharmacological treatments …

Dietary regulation in health and disease

Q Wu, ZJ Gao, X Yu, P Wang - Signal Transduction and Targeted …, 2022 - nature.com
Nutriments have been deemed to impact all physiopathologic processes. Recent evidences
in molecular medicine and clinical trials have demonstrated that adequate nutrition …

Polycystic ovary syndrome: an evolutionary adaptation to lifestyle and the environment

J Parker, C O'brien, J Hawrelak, FL Gersh - International journal of …, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is increasingly recognized as a complex metabolic
disorder that manifests in genetically susceptible women following a range of negative …

Control of immunity via nutritional interventions

N Collins, Y Belkaid - Immunity, 2022 - cell.com
Nutrition affects all physiological processes including those linked to the development and
function of our immune system. Here, we discuss recent evidence and emerging concepts …

The active grandparent hypothesis: Physical activity and the evolution of extended human healthspans and lifespans

DE Lieberman, TM Kistner, D Richard… - Proceedings of the …, 2021 - National Acad Sciences
The proximate mechanisms by which physical activity (PA) slows senescence and
decreases morbidity and mortality have been extensively documented. However, we lack an …

[HTML][HTML] There is urgent need to treat atherosclerotic cardiovascular disease risk earlier, more intensively, and with greater precision: A review of current practice and …

ME Makover, MD Shapiro, PP Toth - American Journal of Preventive …, 2022 - Elsevier
Atherosclerotic cardiovascular disease (ASCVD) is epidemic throughout the world and is
etiologic for such acute cardiovascular events as myocardial infarction, ischemic stroke …

Pursuing human-relevant gut microbiota-immune interactions

SP Spencer, GK Fragiadakis, JL Sonnenburg - Immunity, 2019 - cell.com
The gut microbiota is a complex and plastic network of diverse organisms intricately
connected with human physiology. Recent advances in profiling approaches of both the …

Why deaths of despair are increasing in the US and not other industrial nations—insights from neuroscience and anthropology

P Sterling, ML Platt - JAMA psychiatry, 2022 - jamanetwork.com
The US National Academy of Sciences reports rising mortality for US adults, most steeply for
White adults with a secondary education or less. The rise is largely attributable to deaths of …

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Z Wang, A Emmerich, NJ Pillon, T Moore, D Hemerich… - Nature …, 2022 - nature.com
Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …