Approximately 7 million people are affected by acute myocardial infarction (MI) each year,
and despite significant therapeutic and diagnostic advancements, MI remains a leading …

In this research, we hypothesized that novel biomechanical parameters are discriminative in
patients following acute ST-segment elevation myocardial infarction (STEMI). To identify …

Detailed models of the biomechanics of the heart are important both for developing
improved interventions for patients with heart disease and also for patient risk stratification …

Objectives The ventricle undergoes adverse remodeling after myocardial infarction, resulting
in abnormal biomechanics and decreased function. We hypothesize that tissue-engineered …

Postinfarction remodeling and expansion of the peri-infarct border zone (BZ) directly
correlate with mortality following myocardial infarction (MI); however, the cellular and …

BACKGROUND: Contractility in the borderzone (BZ) after anteroapical myocardial infarction
(MI) is depressed. We tested the hypothesis that BZ contractility is also decreased after …

Decreased contractility in the non-ischemic border zone surrounding a MI is in part due to
degradation of cardiomyocyte sarcomeric components by intracellular matrix …

After myocardial infarction, a poorly contracting nonischemic border zone forms adjacent to
the infarct. The cause of border zone dysfunction is unclear. The goal of this study was to …

Toxicity by recombinant adeno-associated viruses (rAAV) in clinical gene therapy trials (eg,
by rAAV9-mediated fatal liver failure) significantly impairs translation of preclinical rAAV …

In this study, we have developed a human left ventricular model using a hybrid immersed
boundary-finite element description. The left ventricle model is built based on clinical cardiac …