Recent progress of targeted G-quadruplex-preferred ligands toward cancer therapy
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …
rich sequences, and has profound implications for various pharmacological and biological …
Ligand design to acquire specificity to intended G‐quadruplex structures
S Asamitsu, T Bando… - Chemistry–A European …, 2019 - Wiley Online Library
AG‐quadruplex is a nucleic acid secondary structure that is adopted by guanine‐rich
sequences, and is considered to be relevant in various pharmacological and biological …
sequences, and is considered to be relevant in various pharmacological and biological …
Design of Modular G‐quadruplex Ligands
AR Duarte, E Cadoni, AS Ressurreição… - …, 2018 - Wiley Online Library
Guanine‐rich nucleic acid sequences able to form four‐stranded structures (G‐
quadruplexes, G4) play key cellular regulatory roles and are considered as promising drug …
quadruplexes, G4) play key cellular regulatory roles and are considered as promising drug …
Stabilization of G-quadruplex DNA, inhibition of telomerase activity, and tumor cell apoptosis by organoplatinum (II) complexes with oxoisoaporphine
ZF Chen, QP Qin, JL Qin, YC Liu… - Journal of medicinal …, 2015 - ACS Publications
Two G-quadruplex ligands [Pt (La)(DMSO) Cl](Pt 1) and [Pt (Lb)(DMSO) Cl](Pt 2) have been
synthesized and fully characterized. The two complexes are more selective for SK-OV …
synthesized and fully characterized. The two complexes are more selective for SK-OV …
Recent developments in small-molecule ligands of medicinal relevance for harnessing the anticancer potential of G-quadruplexes
L Savva, SN Georgiades - Molecules, 2021 - mdpi.com
G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in
recent years as novel targets, with untapped potential for anticancer research. Their …
recent years as novel targets, with untapped potential for anticancer research. Their …
Quadruplex ligands in cancer therapy
V Sanchez-Martin, M Soriano, JA Garcia-Salcedo - Cancers, 2021 - mdpi.com
Simple Summary Four-stranded nucleic acid secondary structures (quadruplexes) including
DNA G-quadruplexes, RNA G-quadruplexes and i-Motifs display key regulatory functions in …
DNA G-quadruplexes, RNA G-quadruplexes and i-Motifs display key regulatory functions in …
G-quadruplexes in cancer-related gene promoters: from identification to therapeutic targeting
F Romano, A Di Porzio, N Iaccarino… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Guanine-rich DNA sequences can fold into four-stranded noncanonical
secondary structures called G-quadruplexes (G4s) which are widely distributed in functional …
secondary structures called G-quadruplexes (G4s) which are widely distributed in functional …
In vitro and in vivo antitumor activities of three novel binuclear platinum (II) complexes with 4′-substituted-2, 2′: 6′, 2 ″-terpyridine ligands
QP Qin, ZF Wang, SL Wang, DM Luo, BQ Zou… - European Journal of …, 2019 - Elsevier
Herein, we report the design and synthesis of three novel binuclear platinum (II)
complexes,[Pt (tpbtpy) Cl][Pt (DMSO) Cl 3](tpbtpy-Pt),[Pt (dthbtpy) Cl][Pt (DMSO) Cl 3]⋅ CH 3 …
complexes,[Pt (tpbtpy) Cl][Pt (DMSO) Cl 3](tpbtpy-Pt),[Pt (dthbtpy) Cl][Pt (DMSO) Cl 3]⋅ CH 3 …
Targeting G-quadruplex nucleic acids with heterocyclic alkaloids and their derivatives
YX Xiong, ZS Huang, JH Tan - European journal of medicinal chemistry, 2015 - Elsevier
G-Quadruplex nucleic acids or G-quadruplexes (G4s) are four-stranded DNA or RNA
secondary structures that are formed in guanine-rich sequences. They are widely distributed …
secondary structures that are formed in guanine-rich sequences. They are widely distributed …
Flexibility and structural conservation in a c-KIT G-quadruplex
D Wei, J Husby, S Neidle - Nucleic acids research, 2015 - academic.oup.com
A quadruplex sequence from the promoter region of the c-KIT gene forms a stable
quadruplex, as characterized by crystallographic and NMR methods. Two new crystal …
quadruplex, as characterized by crystallographic and NMR methods. Two new crystal …