In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …

Vaccines have had a profound impact on the management and prevention of infectious
disease. In addition, the development of vaccines against chronic diseases has attracted …

Chimeric antigen receptor (CAR) T cell therapy for B cell malignancies has surpassed
expectations, driving an ever-expanding number of clinical trials and the first US Food and …

Chimeric Antigen Receptor T Cells This review addresses T-cell engineering and synthetic
immunity, with a focus on producing durable remissions in patients with treatment-refractory …

Effective antitumour immunity depends on the orchestration of potent T cell responses
against malignancies. Regression of human cancers has been induced by immune …

Adoptive T cell transfer (ACT) is a new area of transfusion medicine involving the infusion of
lymphocytes to mediate antitumor, antiviral, or anti-inflammatory effects. The field has rapidly …

Highlights•CAR T cells are associated with unique side-effects.•Cytokine release syndrome
(CRS), immune effector cell-associated neurotoxicity syndrome (ICANS) and cytopenias are …

Given the global surge in autoimmune diseases, it is critical to evaluate emerging
therapeutic interventions. Despite numerous new targeted immunomodulatory therapies …

Autologous T cells engineered to express chimeric antigen receptor against the B cell
antigen CD19 (CAR19) are achieving marked leukemic remissions in early-phase trials but …

Less than a year since the start of the COVID-19 pandemic, ten vaccines against SARS-CoV-
2 have been approved for at least limited use, with over sixty others in clinical trials. This …