Scientific understanding and clinical management of Dupuytren disease

B Shih, A Bayat - Nature Reviews Rheumatology, 2010 - nature.com
Dupuytren disease (DD) is a fibroproliferative disorder of unknown etiology that often results
in shortening and thickening of the palmar fascia, leading to permanent and irreversible …

A systematic review and meta-analysis on the strength and consistency of the associations between Dupuytren disease and diabetes mellitus, liver disease, and …

DC Broekstra, H Groen, S Molenkamp… - Plastic and …, 2018 - journals.lww.com
Background: The role of diabetes mellitus, liver disease, and epilepsy as risk factors for
Dupuytren disease remains unclear. In this systematic review and meta-analysis, the …

Genetics of Dupuytren's disease

L Michou, JL Lermusiaux, JP Teyssedou, T Bardin… - Joint Bone Spine, 2012 - Elsevier
Dupuytren's disease (DD) is a progressive fibrosis of the palmar fascia characterized by the
formation of a nodule, which evolves into a cord. DD is the most common hereditary disease …

Meta-analysis of genome-wide association studies and network analysis-based integration with gene expression data identify new suggestive loci and unravel a Wnt …

K Becker, S Siegert, MR Toliat, J Du, R Casper… - PLoS …, 2016 - journals.plos.org
Dupuytren´ s disease, a fibromatosis of the connective tissue in the palm, is a common
complex disease with a strong genetic component. Up to date nine genetic loci have been …

In vitro study of novel collagenase (XIAFLEX®) on Dupuytren's disease fibroblasts displays unique drug related properties

F Syed, AN Thomas, S Singh, V Kolluru… - PloS one, 2012 - journals.plos.org
Dupuytren's disease (DD) is a benign, fibroproliferative disease of the palmar fascia, with
excessive extracellular matrix (ECM) deposition and over-production of cytokines and …

The Basic Science of Dupuytren Disease.

AY Zhang, JS Kargel - Hand clinics, 2018 - europepmc.org
Dupuytren disease is a fibroproliferative condition affecting the hands of millions of patients
worldwide. The hypothesis of pathogenesis involves genetic factors and internal factors …

Genome-wide analysis using exon arrays demonstrates an important role for expression of extra-cellular matrix, fibrotic control and tissue remodelling genes in …

HB Forrester, P Temple-Smith, S Ham, D de Kretser… - PLoS …, 2013 - journals.plos.org
Dupuytren's disease (DD) is a classic example of pathological fibrosis which results in a
debilitating disorder affecting a large sector of the human population. It is characterized by …

Update on the role of molecular factors and fibroblasts in the pathogenesis of Dupuytren's disease

M Tripoli, A Cordova, F Moschella - Journal of cell communication and …, 2016 - Springer
The mechanism by which the fibroblast is able to trigger palmar fibromatosis is still not yet
fully understood. It would appear certain that the “abnormal” fibroblasts continuously …

Connective tissue degeneration: Mechanisms of palmar fascia degeneration (Dupuytren's disease)

S Karkampouna, M Kreulen, MC Obdeijn… - Current molecular …, 2016 - Springer
Dupuytren's disease is a connective tissue disorder of the hand causing excessive palmar
fascial fibrosis with associated finger contracture and disability. The aetiology of the disease …

Whole genome and global expression profiling of Dupuytren's disease: systematic review of current findings and future perspectives

B Shih, S Watson, A Bayat - Annals of the rheumatic diseases, 2012 - ard.bmj.com
Dupuytren's disease (DD) is a common fibroproliferative disorder affecting the palmar fascia,
which may lead to permanent contracture of the affected digit. Profiling studies investigating …