MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies
MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …
Skeletal aging and osteoporosis: mechanisms and therapeutics
A Chandra, J Rajawat - International journal of molecular sciences, 2021 - mdpi.com
Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …
homeostasis, which is maintained by an intricate balance between bone formation and bone …
The impact of oxidative DNA damage and stress on telomere homeostasis
RP Barnes, E Fouquerel, PL Opresko - Mechanisms of ageing and …, 2019 - Elsevier
Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear
chromosome ends. Because telomeres shorten progressively with each replication, they …
chromosome ends. Because telomeres shorten progressively with each replication, they …
SIRT6 promotes DNA repair under stress by activating PARP1
Sirtuin 6 (SIRT6) is a mammalian homolog of the yeast Sir2 deacetylase. Mice deficient for
SIRT6 exhibit genome instability. Here, we show that in mammalian cells subjected to …
SIRT6 exhibit genome instability. Here, we show that in mammalian cells subjected to …
An update on PARP inhibitors—moving to the adjuvant setting
A Sonnenblick, E De Azambuja, HA Azim Jr… - Nature reviews Clinical …, 2015 - nature.com
Inhibition of poly (ADP-ribose) polymerase (PARP) enzymes is a potential synthetic lethal
therapeutic strategy in cancers harbouring specific DNA-repair defects, including those …
therapeutic strategy in cancers harbouring specific DNA-repair defects, including those …
Telomere states and cell fates
EH Blackburn - Nature, 2000 - nature.com
Telomere length has frequently been used as a means to predict the future life of cells. But
by itself it can be a poor indicator of ageing or cell viability. What, then, is the important …
by itself it can be a poor indicator of ageing or cell viability. What, then, is the important …
[HTML][HTML] PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies
JM Lee, JA Ledermann, EC Kohn - Annals of oncology, 2014 - Elsevier
Poly (ADP-ribose) polymerase inhibitors (PARPis) have shown promising activity in patients
with BRCA1/2 mutation-associated (BRCA1/2 MUT+) ovarian and breast cancers …
with BRCA1/2 mutation-associated (BRCA1/2 MUT+) ovarian and breast cancers …
The power to reduce: pyridine nucleotides–small molecules with a multitude of functions
N Pollak, C Dölle, M Ziegler - Biochemical Journal, 2007 - portlandpress.com
The pyridine nucleotides NAD and NADP play vital roles in metabolic conversions as signal
transducers and in cellular defence systems. Both coenzymes participate as electron …
transducers and in cellular defence systems. Both coenzymes participate as electron …
The enigmatic function of PARP1: from PARylation activity to PAR readers
T Kamaletdinova, Z Fanaei-Kahrani, ZQ Wang - Cells, 2019 - mdpi.com
Poly (ADP-ribosyl) ation (PARylation) is catalysed by poly (ADP-ribose) polymerases
(PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes. Poly …
(PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes. Poly …
4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1
KA Menear, C Adcock, R Boulter… - Journal of medicinal …, 2008 - ACS Publications
Poly (ADP-ribose) polymerase activation is an immediate cellular response to metabolic-,
chemical-, or ionizing radiation-induced DNA damage and represents a new target for …
chemical-, or ionizing radiation-induced DNA damage and represents a new target for …