Development of phenothiazine hybrids with potential medicinal interest: a review

MC Posso, FC Domingues, S Ferreira, S Silvestre - Molecules, 2022 - mdpi.com
The molecular hybridization approach has been used to develop compounds with improved
efficacy by combining two or more pharmacophores of bioactive scaffolds. In this context …

Recent advances on visible light Phenothiazine-based photoinitiators of polymerization

F Dumur - European Polymer Journal, 2022 - Elsevier
Visible light photoinitiators of polymerization are actively researched as these molecules can
advantageously address the light penetration issue within the photocurable resins. With aim …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: A decade update

K Laxmikeshav, P Kumari… - Medicinal Research …, 2022 - Wiley Online Library
This review article proposes a comprehensive report of the design strategies engaged in the
development of various sulfur‐bearing cytotoxic agents. The outcomes of various studies …

Insight into the role of clathrin‐mediated endocytosis inhibitors in SARS‐CoV‐2 infection

SS Alkafaas, AM Abdallah, S Ghosh… - Reviews in Medical …, 2023 - Wiley Online Library
Emergence of SARS‐CoV‐2 variants warrants sustainable efforts to upgrade both the
diagnostic and therapeutic protocols. Understanding the details of cellular and molecular …

Identification of a drug targeting an intrinsically disordered protein involved in pancreatic adenocarcinoma

JL Neira, J Bintz, M Arruebo, B Rizzuti, T Bonacci… - Scientific reports, 2017 - nature.com
Intrinsically disordered proteins (IDPs) are prevalent in eukaryotes, performing signaling and
regulatory functions. Often associated with human diseases, they constitute drug …

Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral …

AJ Jhou, HC Chang, CC Hung, HC Lin, YC Lee… - Biochemical …, 2021 - Elsevier
Abstract Chlorpromazine (CPZ), an FDA-approved phenothiazine derivative used to treat
schizophrenia and other psychiatric disorders, has been demonstrated to have potential anti …

Recent advances on visible light Thiophene-based photoinitiators of polymerization

F Dumur - European Polymer Journal, 2022 - Elsevier
Visible light photopolymerization has given a revival of interest to photopolymerization due
to its recent use in 3D printing. With aim at developing visible light photoinitiating systems …

Synergistic growth inhibition of HT-29 colon and MCF-7 breast cancer cells with simultaneous and sequential combinations of antineoplastics and CNS drugs

D Duarte, A Cardoso, N Vale - International Journal of Molecular Sciences, 2021 - mdpi.com
Several central nervous system (CNS) drugs exhibit potent anti-cancer activities. This study
aimed to design a novel model of combination that combines different CNS agents and …

Drug Combinations: A New Strategy to Extend Drug Repurposing and Epithelial-Mesenchymal Transition in Breast and Colon Cancer Cells

D Duarte, A Rêma, I Amorim, N Vale - Biomolecules, 2022 - mdpi.com
Despite the progressive research and recent advances in drug therapy to treat solid
tumours, the number of cases and deaths in patients with cancer is still a major health …