Machine learning in pharmacometrics: Opportunities and challenges

M McComb, R Bies… - British Journal of Clinical …, 2022 - Wiley Online Library
The explosive growth in medical devices, imaging and diagnostics, computing, and
communication and information technologies in drug development and healthcare has …

Detection of drug–drug interactions through data mining studies using clinical sources, scientific literature and social media

S Vilar, C Friedman, G Hripcsak - Briefings in bioinformatics, 2018 - academic.oup.com
Drug–drug interactions (DDIs) constitute an important concern in drug development and
postmarketing pharmacovigilance. They are considered the cause of many adverse drug …

How can natural language processing help model informed drug development?: a review

R Bhatnagar, S Sardar, M Beheshti, JT Podichetty - JAMIA open, 2022 - academic.oup.com
Objective To summarize applications of natural language processing (NLP) in model
informed drug development (MIDD) and identify potential areas of improvement. Materials …

[HTML][HTML] AI and the Evolution of Personalized Medicine in Pharmacogenomics

H Taherdoost, A Ghofrani - Intelligent Pharmacy, 2024 - Elsevier
This paper examines the transformative impact of artificial intelligence (AI) on
pharmacogenomics, signaling a paradigm shift in personalized medicine. With a focus on …

Past and future uses of text mining in ecology and evolution

MJ Farrell, L Brierley, A Willoughby… - Proceedings of the …, 2022 - royalsocietypublishing.org
Ecology and evolutionary biology, like other scientific fields, are experiencing an
exponential growth of academic manuscripts. As domain knowledge accumulates, scientists …

[HTML][HTML] Signal detection in pharmacovigilance: a review of informatics-driven approaches for the discovery of drug-drug interaction signals in different data sources

H Ibrahim, A Abdo, AM El Kerdawy, AS Eldin - Artificial intelligence in the …, 2021 - Elsevier
The objective of this article is to review the application of informatics-driven approaches in
the pharmacovigilance field with focus on drug-drug interaction (DDI) safety signal discovery …

Integrating clinical pharmacology and artificial intelligence: potential benefits, challenges, and role of clinical pharmacologists

H Singh, DK Nim, AS Randhawa… - Expert Review of …, 2024 - Taylor & Francis
Introduction The integration of artificial intelligence (AI) into clinical pharmacology could be a
potential approach for accelerating drug discovery and development, improving patient care …

Annotation and detection of drug effects in text for pharmacovigilance

P Thompson, S Daikou, K Ueno… - Journal of …, 2018 - Springer
Pharmacovigilance (PV) databases record the benefits and risks of different drugs, as a
means to ensure their safe and effective use. Creating and maintaining such resources can …

[HTML][HTML] Undergraduate biocuration: developing tomorrow's researchers while mining today's data

CS Mitchell, A Cates, RB Kim… - Journal of Undergraduate …, 2015 - ncbi.nlm.nih.gov
Biocuration is a time-intensive process that involves extraction, transcription, and
organization of biological or clinical data from disjointed data sets into a user-friendly …

Translational high‐dimensional drug interaction discovery and validation using health record databases and pharmacokinetics models

CW Chiang, P Zhang, X Wang, L Wang… - Clinical …, 2018 - Wiley Online Library
Polypharmacy increases the risk of drug–drug interactions (DDIs). Combining
epidemiological studies with pharmacokinetic modeling, we detected and evaluated high …