Background Neuroplasticity refers to the inherently dynamic biological capacity of the central
nervous system (CNS) to undergo maturation, change structurally and functionally in …

Perinatal hypoxia-ischemia remains the primary cause of acute neonatal brain injury,
leading to a high mortality rate and long-term neurological deficits, such as behavioral …

Perinatal brain injury (PBI) in preterm birth is associated with substantial injury and
dysmaturation of white and gray matter, and can lead to severe neurodevelopmental deficits …

Aims Hypoxic–ischemic brain injury (HIBI) often results in cognitive impairments. Herein, we
investigated the roles of ferroptosis in HIBI and the underlying signaling pathways. Methods …

Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs
through over-stimulation of glutamate receptors, specifically NMDAR, while in the non …

Significance: Tetrahydrobiopterin (BH4) is most well known as a required cofactor for
enzymes regulating cellular redox homeostasis, aromatic amino acid metabolism, and …

Background Neonatal hypoxic-ischemic (HI) insult is a leading cause of disability and death
in newborns, with therapeutic hypothermia being the only currently available clinical …

Perinatal asphyxia often results in neonatal cerebral hypoxia-ischemia (HI), which is
associated with high mortality and severe long-term neurological deficits in newborns …

Neonatal hypoxic-ischemic encephalopathy (HIE) is an obstinate disease that troubles
neonatologists. At present, cognitive impairment after HIE has received increasing attention …

The brain is one of the main organs affected by hypoxia and reoxygenation in the neonatal
period and one of the most vulnerable to oxidative stress. Hypoxia/ischemia and …