Acute myeloid leukemia (AML) is the most common acute leukemia in adults. While survival
for younger patients over the last several decades has improved nearly sixfold with the …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

Histones are subject to a vast array of posttranslational modifications including acetylation,
methylation, phosphorylation, and ubiquitylation. The writers of these modifications play …

TP53 (which encodes p53 protein) is the most frequently mutated gene among all human
cancers. Prevalent p53 missense mutations abrogate its tumour suppressive function and …

The BAP1 gene has emerged as a major tumor suppressor mutated with various
frequencies in numerous human malignancies, including uveal melanoma, malignant …

The molecular pathogenesis of renal cell carcinoma (RCC) is poorly understood. Whole-
genome and exome sequencing followed by innovative tumorgraft analyses (to accurately …

Pancreatic neuroendocrine tumors (PanNETs) are a rare but clinically important form of
pancreatic neoplasia. To explore the genetic basis of PanNETs, we determined the exomic …

The Saccharomyces cerevisiae Set1/COMPASS was the first histone H3 lysine 4 (H3K4)
methylase identified over 10 years ago. Since then, it has been demonstrated that …

Multiple endocrine neoplasia (MEN) is characterized by the occurrence of tumors involving
two or more endocrine glands within a single patient. Four major forms of MEN, which are …